Abstract

http://ssrn.com/abstract=1320003
 


 



Detecting the Genetic Signature of Natural Selection in Human Populations: Models, Methods, and Data


Angela M. Hancock


University of Chicago

Anna DiRienzo


University of Chicago - Department of Anthropology

December, 23 2008

Annual Review of Anthropology, Vol. 37, October 2008

Abstract:     
Patterns of DNA sequence variation in the genome contain a record of past selective events. The ability to collect increasingly large data sets of polymorphisms has allowed investigators to perform hypothesis-driven studies of candidate genes as well as genome-wide scans for signatures of adaptations. This genetic approach to the study of natural selection has identified many signals consistent with predictions from anthropological studies. Selective pressures related to variation in climate, diet, and pathogen exposure have left strong marks on patterns of human variation. Additional signals of adaptations are observed in genes involved in chemosensory perception and reproduction. Several ongoing projects aim to sequence the complete genome of 1000 individuals from different human populations. These large-scale projects will provide data for more complete genome scans of selection, but more focused studies aimed at testing specific hypotheses will continue to hold an important place in elucidating the history of adaptations in humans.

Keywords: genetic adaptations, selective sweeps, neutrality tests

Accepted Paper Series


Not Available For Download

Date posted: December 23, 2008  

Suggested Citation

Hancock, Angela M. and diRienzo, Anna, Detecting the Genetic Signature of Natural Selection in Human Populations: Models, Methods, and Data (December, 23 2008). Annual Review of Anthropology, Vol. 37, October 2008. Available at SSRN: http://ssrn.com/abstract=1320003

Contact Information

Angela M. Hancock
University of Chicago ( email )
1101 East 58th Street
Chicago, IL 60637
United States
Anna DiRienzo (Contact Author)
University of Chicago - Department of Anthropology ( email )
Illinois, IL 60637
United States
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