Response-Adaptive Designs for Clinical Trials: Simultaneous Learning from Multiple Patients
University of Chicago - National Organization for Research (NORC)
John R. Birge
University of Chicago - Booth School of Business
July 4, 2014
Clinical trials have traditionally followed a fixed design, in which patient allocation to treatments is fixed throughout the trial and specified in the protocol. The primary goal of this static design is to learn about the efficacy of treatments. Response-adaptive designs, on the other hand, allow clinicians to use the learning about treatment effectiveness to dynamically adjust patient allocation to treatments as the trial progresses. An ideal adaptive design is one where patients are treated as effectively as possible without sacrificing potential learning or compromising the integrity of the trial. We propose such a design, one that uses forward-looking algorithms to fully exploit learning from multiple patients simultaneously. Compared to the best existing implementable adaptive design (e.g. using Berry, 1978), we show that our proposed design improves patient outcomes by up to 8.6% under a set of considered scenarios. Further, we demonstrate our design's effectiveness using data from a recently conducted stent trial. The design is general and applicable to any Markov decision process setting where learning takes place from multiple simultaneous individual experiments as, for example, in customized consumer offers. This paper also adds to the general understanding of such models by showing the value and nature of improvements over heuristic solutions for problems with short delays in observing patient outcomes. We do this by showing the relative performance of these schemes for maximum expected health and maximum expected learning objectives, and by demonstrating the value of a truncated-horizon approximation in a practical example.
Number of Pages in PDF File: 39
Keywords: OR in health services; Adaptive clinical trials; Markov decision process; Bayesian learning; Stents
JEL Classification: C11, C44, I18working papers series
Date posted: August 10, 2012 ; Last revised: July 5, 2014
© 2014 Social Science Electronic Publishing, Inc. All Rights Reserved.
This page was processed by apollo1 in 0.328 seconds