Abstract

http://ssrn.com/abstract=2428820
 
 

References (51)



 


 



Positioning Inventory in Clinical Trial Supply Chains


Adam Fleischhacker


University of Delaware

Anh Ninh


Rutgers, The State University of New Jersey - Rutgers Center for Operations Research (RUTCOR)

Yao Zhao


Rutgers, The State University of New Jersey - Rutgers University, Newark

April 24, 2014


Abstract:     
As a result of slow patient recruitment and high patient costs in the United States, clinical trials are increasingly going global. While recruitment efforts benefit from a larger global footprint, the supply chain has to work harder at getting the right drug supply, to the right place, at the right time. Certain clinical trial supply chains, especially those supplying biologics, have a combination of unique attributes that have yet to be addressed by existing supply chain models. These attributes include a fixed patient horizon, an inflexible supply process, a unique set of service-level requirements, and an inability to transfer drug supplies among testing sites. In this paper, we provide a new class of multi-echelon inventory models to address these unique aspects. The resulting mathematical program is a nonlinear integer programming problem with chance constraints. Despite this complexity, we develop a solution method that transforms the original formulation into a linear integer equivalent. By analyzing special cases and through numerical study of both real-life and simulated examples, we develop novel insights into inventory positioning and the cost drivers in clinical trial supply chains.

Number of Pages in PDF File: 38

Keywords: clinical trial supply chain, multi-echelon inventory models, finite patient horizon

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Date posted: April 26, 2014  

Suggested Citation

Fleischhacker, Adam and Ninh, Anh and Zhao, Yao, Positioning Inventory in Clinical Trial Supply Chains (April 24, 2014). Available at SSRN: http://ssrn.com/abstract=2428820 or http://dx.doi.org/10.2139/ssrn.2428820

Contact Information

Adam Fleischhacker (Contact Author)
University of Delaware ( email )
Newark, DE
United States
Anh Ninh
Rutgers, The State University of New Jersey - Rutgers Center for Operations Research (RUTCOR) ( email )
New Brunswick, NJ 08903
United States
Yao Zhao
Rutgers, The State University of New Jersey - Rutgers University, Newark ( email )
180 University Avenue
Newark, NJ 07102
United States
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References:  51

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