See all articles by Liyuan RanDalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - National Center of Genetically Engineered Animal Models for International Research
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University - Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - National Center of Genetically Engineered Animal Models for International Research
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University - Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases ; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University - Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University - National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University - Liaoning Provence Key Lab of Genome Engineered Animal Models
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research
Dalian Medical University, Department of Pathophysiology
University of Minnesota - Twin Cities - Department of Food Science and Nutrition
Icahn Mount Sinai School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease
Yunnan University - Center for Life Sciences; Chinese Academy of Sciences (CAS) - Key Laboratory of Animal Models and Human Disease Mechanisms
New York University (NYU) - Department of Molecular Pathobiology; New York University (NYU) - Department of Basic Science and Craniofacial Biology; New York University (NYU) - Department of Urology; New York University (NYU) - Laura and Isaac Perlmutter Cancer Center
Dalian Medical University, Institute for Genome Engineered Animal Models of Human Diseases ; Dalian Medical University, National Center of Genetically Engineered Animal Models for International Research; Dalian Medical University, Liaoning Provence Key Lab of Genome Engineered Animal Models; Dalian Medical University - College of Integrative Medicine; Icahn Mount Sinai School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease; New York University (NYU), College of Dentistry, Department of Basic Science and Craniofacial Biology
Abstract
Growth hormone (GH) binds to its receptor GHR to exert its pleiotropic effects on growth and metabolism. Disproportionate GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in murine models with global or tissue-specific GHR deficiency and clinical observations. Here we constructed an adipose-specific GHR knockout mouse model Ad-GHRKO and studied the metabolic adaptability of the mice when stressed by high-fat diet (HFD) or cold. We found that disruption of adipose GHR accelerated the dietary obesity but protected the liver from ectopic adiposity through free fatty acid trapping. The heat-producing BAT burning and WAT browning induced by cold were retarded in absence of adipose GHR but was recovered after prolonged cold acclimation. We conclude that at the expense of excessive subcutaneous fat accumulation and lower emergent cold tolerance, down-tuning adipose GHR signalling emulates a healthy obesity situation which has metabolic advantages against HFD.
Ran, Liyuan and Wang, Xiaoshuang and Mi, Ai and Liu, Yanshuang and Wu, Jin and Guo, Meihua and Sun, Jie and Liu, Bo and Li, Youwei and Wang, Dan and Jiang, Rujiao and Wang, Ning and Gao, Wenting and Zeng, Li and Huang, Lin and Chen, Xiaoli and LeRoith, Derek and Liang, Bin and Li, Xin and Wu, Yingjie, Loss of Adipose GHR in Mice Enhances Local Fatty Acid Trapping and Impairs BAT Thermogenesis (February 8, 2019). Available at SSRN:
https://ssrn.com/abstract=3331242 or
http://dx.doi.org/10.2139/ssrn.3331242
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