Adjuvant and Formulation Considerations for a Subunit Blood-Stage Malaria Vaccine

Abstract

Protection against malaria from a vaccine requires modulation of the immune response to malaria antigens. This modulation by pathogen-derived molecules is explored in this study. Human immune cells synergistically express signaling proteins when stimulated by certain combinations of pathogen-derived molecules. Some of these expression profiles indicate a Th1-mediated immune response, which may be the immune response needed for the next-generation malaria of vaccines, in terms of effectiveness.

Keywords: malaria, vaccine, public health