From research to clinical practice: Consensus guidelines for Neuroimaging AI tools for the Memory clinic (Neuro-AIM)

19 Pages Posted: 7 Oct 2025

See all articles by Natasha Clarke

Natasha Clarke

University of Montreal - Department of Psychology

Mathias Huybrechts

University of Antwerp

Jay Amin

University of Southampton

Lewis Hotchkiss

Swansea University

James Leighs

University College London - University College London Hospitals NHS Foundation Trust

Matthew Leming

Harvard University - Massachusetts General Hospital

Usman Saeed

University of Toronto

Catherine J. Scott

University College London - University College London Hospitals NHS Foundation Trust

Dirk Smeets

Clinical Trials, Belgium - icometrix; Vrije Universiteit Brussel (VUB)

Angela Tam

affiliation not provided to SSRN

Stefano Tamburin

University of Verona - Department of Neurosciences, Biomedicine and Movement Sciences

Geert Vanhooren

AZ Sint-Jan Brugge AV

Meike W. Vernooij

Erasmus University Rotterdam (EUR) - Department of Epidemiology; Erasmus MC University Medical Center

Jennifer Camaradou

PIH Plymouth Institute of Health

David J. Llewellyn

University of Exeter

Timothy Rittman

University of Cambridge - Department of Clinical Neurosciences

Rose Bruffaerts

University of Antwerp

Date Written: October 03, 2025

Abstract

Although AI tools for neuroimaging show considerable promise in the diagnosis, prognosis, and management of neurodegenerative disorders, their uptake in memory clinics has been limited. A key barrier is lack of consensus on their effective design and implementation. Here we establish consensus guidelines addressing the specific goals, usage and challenges of AI tools for neuroimaging in the memory clinic using a Delphi consensus process. Sixteen experts from clinical, academic, and industry backgrounds participated in three rounds of questionnaires, coordinated by the Imaging Working Group of the Deep Dementia Phenotyping (DEMON) network, with support from a patient and public involvement representative. Consensus was reached on eight statements covering four themes: purpose, quality, interactions with clinicians and memory clinics, and privacy and ethics. Implementation of the guidelines will further the adoption of AI neuroimaging tools from research to clinical practice, improving diagnostic and care pathways for patient benefit. 

Keywords: neuroimaging, artificial intelligence, memory clinics, dementia, neurology, guidelines, delphi, AI, ethics, patient care, neurodegenerative disorders

Suggested Citation

Clarke, Natasha and Huybrechts, Mathias and Amin, Jay and Hotchkiss, Lewis and Leighs, James and Leming, Matthew and Saeed, Usman and Scott, Catherine J. and Smeets, Dirk and Tam, Angela and Tamburin, Stefano and Vanhooren, Geert and Vernooij, Meike W. and Camaradou, Jennifer and Llewellyn, David J. and Rittman, Timothy and Bruffaerts, Rose, From research to clinical practice: Consensus guidelines for Neuroimaging AI tools for the Memory clinic (Neuro-AIM) (October 03, 2025). Available at SSRN: https://ssrn.com/abstract=5560399 or http://dx.doi.org/10.2139/ssrn.5560399

Natasha Clarke

University of Montreal - Department of Psychology ( email )

Montréal
Canada

Mathias Huybrechts

University of Antwerp ( email )

Jay Amin

University of Southampton ( email )

Lewis Hotchkiss

Swansea University ( email )

James Leighs

University College London - University College London Hospitals NHS Foundation Trust ( email )

Matthew Leming

Harvard University - Massachusetts General Hospital

55 Fruit Street Boston
Boston, MA 02114
United States

Usman Saeed

University of Toronto ( email )

Catherine J. Scott

University College London - University College London Hospitals NHS Foundation Trust ( email )

Dirk Smeets

Clinical Trials, Belgium - icometrix ( email )

Leuven
Belgium

Vrije Universiteit Brussel (VUB) ( email )

Angela Tam

affiliation not provided to SSRN ( email )

Stefano Tamburin

University of Verona - Department of Neurosciences, Biomedicine and Movement Sciences ( email )

Verona
Italy

Geert Vanhooren

AZ Sint-Jan Brugge AV ( email )

Ruddershove 10
Brugge, 8000
Belgium

Meike W. Vernooij

Erasmus University Rotterdam (EUR) - Department of Epidemiology ( email )

Rotterdam
Netherlands

Erasmus MC University Medical Center ( email )

Dr. Molewaterplein 40
Rotterdam, 3015 GD
Netherlands

Jennifer Camaradou

PIH Plymouth Institute of Health ( email )

David J. Llewellyn

University of Exeter ( email )

Timothy Rittman

University of Cambridge - Department of Clinical Neurosciences ( email )

Rose Bruffaerts (Contact Author)

University of Antwerp ( email )

Prinsstraat 13
Antwerp, 2000
Belgium

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