Download This Paper
An Assessment of Stellate Ganglion Neuronal Remodeling in Association with Cardiovascular Disease
34 Pages Posted: 1 Apr 2020 Publication Status: Review Complete
More...Abstract
Greater neuron density, and therefore neuronal remodeling, in the stellate ganglion has been associated with cardiovascular disease, but how this remodeling differs between cardiovascular conditions has not yet been investigated. Here, we have demonstrated a significant increase in neuronal size from individuals with no cardiovascular pathology to those with coronary artery disease or those who have experienced a myocardial infarction; however, this increase was not found to be significant in individuals with heart failure diagnoses. Heat map analysis of neuron nearest-neighbor densities additionally showed clustering, or closeness of neurons, in coronary artery disease and heart failure patients, but this clustering was not noted in individuals who had experienced a myocardial infarction. These observations may allude to differences in the role the sympathetic nervous system plays, and therefore differences in the disease progression, in these cardiovascular conditions.
Keywords: myocardial infarction, heart failure, coronary artery disease, stellate ganglion remodeling, heat map
Suggested Citation: Suggested Citation