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Modeling of MicroRNA-Derived Disease Network Repurposes Methotrexate for the Prevention and Therapy of Abdominal Aortic Aneurysm
40 Pages Posted: 14 Apr 2020 Publication Status: Review Complete
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Highlights
● We presented a computational model to built human disease network from miRNA-disease association data;
● Applying the presented model, we built a miRNA-derived human disease network which covers 15 disease classes and includes 304 diseases;
● We revealed a number of patterns for the disease network, for example diseases tend to be clustered and coherent in the network;
● We repurposed methotrexate, a drug for autoimmune disease, to be a possible drug to prevent the formation and inhibit the development of AAA, a common serious disease without drugs in clinics.
Keywords: network medicine, miRNA, disease, abdominal aortic aneurysm (AAA), drug repurposing
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