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Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection
29 Pages Posted: 15 Apr 2020 Publication Status: Published
More...Abstract
Type 1 interferon (IFN) plays a critical role in early antiviral defense and priming of adaptive immunity by upgregulating interferon-stimulated genes (ISGs). Certain stimuli trigger strong activation of IFN regulatory factor 3 (IRF3) and direct upregulation of ISGs in addition to IFN. We found that UV-inactivated human cytomegalovirus (HCMV) particles triggered an IFN-independent ISG signature while UV-inactivated Sendai virus (SeV) particles did not. HCMV particles triggered uniform activation of IRF3 and low-level IFN-
Keywords: Interferon, innate immunity sensing, Antiviral, enveloped virus particles, vector, dsRNA
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