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Incidence of Down's Syndrome by Maternal Age of Asian Population
8 Pages Posted: 24 Jun 2020
More...Abstract
Objectives: To study the incidence of Down's syndrome by maternal age of the Asian population.
Setting and Design: Data on prenatal serum screening between 2008-2017 was obtained from the Maternal and Child Hospital of Hubei Province. Cases were classified into three groups: ≤26-year-old, 27-33-year-old, and ≥34-year-old. The prevalence of Down's Syndrome was calculated for each age and age bracket separately, and the difference between different groups was analyzed with the chi-square test.
Results: The incidence of Down’s syndrome in maternal age of ≤26-year-old, 27-33-year-old, and ≥34-year-old was 0.67 ‰, 0.29 ‰, and 2.07 ‰, respectively. There were significant differences among different age groups (χ 2 = 79.748, P < 0.05).
Conclusion: In the population investigated, the incidence of Down’s syndrome in maternal age over 34 is much higher than that of the 27-33-year-old group, while younger women aged under 26 are also subject to a higher risk.
Funding Statement: This work was supported by Hubei Provincial Health and Family Planning Scientific Research Project [Grant # WJ2018H0137].
Declaration of Interests: The authors have no conflicts of interest relevant to this article.
Ethics Approval Statement: The research was approved by the Ethics Committee of Maternal and Child Health Hospital of Hubei Province. All patient guardians gave informed consent to the study.
Keywords: Down's Syndrome, Incidence, Maternal Age, Asian Population
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