An Approach Towards Quorum Inhibition in Pathogen Pseudomonas aeruginosa by Herbal Plant Extracts and Phytochemicals

The principle cause of micro-organism contagion is virulence regulated by Quorum Sensing (QS) phenomenon. So the present study is aimed to discover the Anti-Quorum (AQ) sensing activity of 4 crude plant extracts and 3 pure phytochemicals. The AQ compound was found to be present in a few of the extracts which demonstrated inhibition against virulence pigment pyocyanin production in Pseudomonas aeruginosa (MTCC 1688). Green Tea extract and Gallic Acid pure phytochemicals were found to be the potential compounds to give AQ activity with less effect on bacterial growth. As per the results attained by gas chromatography-mass spectroscopy (GC-MS), it can be concluded that caffeine could have Anti-Quorum activity.

Keywords: Quorum Sensing, Pseudomonas aeruginosa, Pyocyanin, Biofilm-production, AHL, Growth-Curve

Suggested Citation: Suggested Citation

Jadeja, Nileshwariba and Changela, Disha and Dangar, Kruti G. and Bhatt, Aditya and Raval, Mihir, An Approach Towards Quorum Inhibition in Pathogen Pseudomonas aeruginosa by Herbal Plant Extracts and Phytochemicals (April 9, 2020). Proceedings of the National Conference on Innovations in Biological Sciences (NCIBS) 2020, Available at SSRN: https://ssrn.com/abstract=3572636 or http://dx.doi.org/10.2139/ssrn.3572636