Download This PaperIn Silico Analysis of Hypothetical Proteins of Haemophilus Influenzae PittGG Strain
15 Pages Posted: 15 Apr 2020 Last revised: 8 Jun 2020
Date Written: April 12, 2020
Abstract
The complete genome of an organism in public data is a milestone to understand the blueprint of life. As of March 06, 2020, 372archaeal, 16,976 bacterial complete genomes are available and 122,925 contigs and 96,750 scaffolds from bacteria and 2,175 contigs and 1,744 scaffolds, from archaeal genomes, are in progress. The traditional experiments are helping to investigate the function of genes in the genome. Haemophilus influenza PittGG bacterium is one of the leading causes of meningitis in young children, and it may also cause septicemia, otitis media, sinusitis, and chronic bronchitis. It has 482 hypothetical proteins. The determination of this protein function is one of the challenging problems of the post-genome era. That demands bioinformatics tools such as BLAST, InterProScan, Cogniter, CDD, TMHMM, PFP, ProFAT, Protfun, Prodom, Pfam, phyre and Meta server the functional annotation of hypothetical protein of un-annotated protein sequences. This kind of experiment is time-consuming and costly the complete sequence of genomes also has potential in various diseases, annotation of this genes may help to treat diseases.
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