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Fas -670 A/G Polymorphism Predicts Prognosis of Hepatocellular Carcinoma after Curative Resection in Chinese Han Population
26 Pages Posted: 10 Aug 2020
More...Abstract
Background: Apoptosis, also called programmed cell death, is a genetically controlled process against hyperproliferation and malignancy. The Fas-Fas ligand (FasL) system is considered to be a major pathway for apoptosis in cells and tissues. Thus, this study aimed to investigate whether single nucleotide polymorphisms (SNPs) in Fas and FasL gene may have effects on the recurrence and survival of patients with hepatocellular carcinoma (HCC) after curative hepatectomy.
Methods: We studied the relationship between Fas rs1800682, rs2234767 and FasL rs763110 polymorphisms and recurrence-free survival (RFS) as well as overall survival (OS) in 117 Chinese Han patients with HCC that underwent hepatectomy.
Findings: In Kaplan–Meier survival analysis, only Fas rs1800682 (-670 A/G) was identified to be associated with RFS and OS. Compared with AA genotype, the AG/GG genotypes was significantly associated with better RFS (p = 0.008) and OS (p = 0.020). Moreover, multivariate Cox regression analysis showed that Fas rs1800682 remained as a significant independent predictor in RFS for the resected HCC patients (AG/GG vs. AA; adjusted HR 0.464, 95% CI 0.275-0.782, p=0.004), but is not an independent predictor in OS (p=0.395).
Interpretation: This study demonstrated that Fas -670 G allele may play a protective role in the recurrence and survival of HCC patients with hepatectomy. Furthermore, Fas rs1800682 polymorphism might be a promising biomarker for HCC patients after hepatectomy.
Funding Statement: This work was supported by grants from the Sichuan Science and Technology Program (No 2019YFS0370) and national university student innovation and entrepreneurship training programs (No C2019104465).
Declaration of Interests: No potential conflicts of interest were disclosed.
Ethics Approval Statement: This study was coincident with Declaration of Helsinki, and approved by the Ethics Committee of Sichuan University.
Keywords: hepatocellular carcinoma (HCC); single nucleotide polymorphisms (SNPs); cell apoptosis; prognosis; resection
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