Central South University - Department of Nuclear Medicine
Abstract
Injectable hydrogel embedded with ultra-small bismuth sulfide (Bi2S3) nanodots (~ 2 nm) is prepared through a one-pot synthesis method that uses anionic polysaccharide gellan gum (GG) as a stabilizer. The as-prepared Bi 2S3 @GG hydrogel displays excellent capability for both photothermal therapy (PTT) (the photothermal conversion efficiency of 44.3%) and X-ray computed tomography (the X-ray absorption coefficient of 51.5 HU L·g -1 ), integrating with real-time monitoring and therapeutic functions. After incorporation with sorafenib (SF), the hydrogel shows a sustained release of SF over 15 days. The mice receiving the combined treatments of photothermal-chemotherapy show a tumor suppression rate of 98.2% by 22 days after the treatment. In contrast, tumor growth and recurrence are observed in the single treatment. Our work presents a new strategy to construct a theranostic hydrogel platform for a safe and precise antitumor therapy.
Wu, Yingjiao and Liang, Yuqing and Liu, Yandi and Hao, Yijun and Tao, Na and Li, Juan and Sun, Xiaoyi and Liu, You-Nian and Zhou, Ming, Bismuth Sulfide Nanodots Embedded Hydrogel as Theranostic Platform for CT Imaging and Photothermal/Antiangiogenic Therapy. Available at SSRN: https://ssrn.com/abstract=3687903 or http://dx.doi.org/10.2139/ssrn.3687903
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