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High Alcohol-Producing Klebsiella Pneumonia is a Bacterial Culprit of Fatty Liver Disease

125 Pages Posted: 23 Apr 2019 Last revised: 7 Oct 2019 Publication Status: Published

See all articles by Jing Yuan

Jing Yuan

Capital Institute of Pediatrics

Xiao Wei

Academy of Military Sciences - Center for Disease Control and Prevention

Xiangna Zhao

Academy of Military Sciences - Center for Disease Control and Prevention

Chen Chen

Capital Medical University - Institute of Infectious Diseases

Jing Lu

Capital Institute of Pediatrics

Weiwei Cheng

Capital Institute of Pediatrics

Boxin Li

Capital Institute of Pediatrics

Huan Li

Academy of Military Sciences - Center for Disease Control and Prevention

Weishi Lin

Academy of Military Sciences - Center for Disease Control and Prevention

Changyu Tian

Academy of Military Sciences - Center for Disease Control and Prevention

Jiangtao Zhao

Academy of Military Sciences - Center for Disease Control and Prevention

Juqiang Han

PLA Army General Hospital - Institute of Hepatology

Daizhi An

Academy of Military Sciences - Center for Disease Control and Prevention

Hong Wei

Huazhong Agricultural University - The Engineering Technology Research Center for Germ-free and Genome-editing Animal

Minghua Zheng

Wenzhou Medical University - Department of Hepatology

Xuejun Ma

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Institute for Viral Disease Control and Prevention

Wei Li

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology

Xuesong Wang

Academy of Military Sciences - Center for Disease Control and Prevention

Xiao Chen

Capital Institute of Pediatrics

Zheng Zhang

Capital Institute of Pediatrics

Hui Zeng

Capital Medical University - Institute of Infectious Diseases

Sun Ying

Capital Medical University - Department of Immunology

JianXin Wu

Capital Institute of Pediatrics

Ruifu Yang

Academy of Military Sciences - Beijing Institute of Microbiology and Epidemiology

Di Liu

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology

More...

Abstract

Nonalcoholic fatty liver disease (NAFLD), a prelude to cirrhosis and hepatocellular carcinoma, was considered to be associated with gut microbiota. However, causal relationship between microbiota and NAFLD remains unclear. We showed that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) was significantly associated with up to 60% of NAFLD patients. Gavage administration of HiAlc Kpn induced typical pathological changes of hepatic steatosis and similar gene expression profiles in NAFLD murine, compared to those of alcohol intake. Comprehensive investigations in mice including gnotobiotic gavage and microbiota transplant demonstrated that HiAlc Kpn strains are the causative agents of NAFLD and lead to mitochondrial dysfunction and steatosis through 2,3-butanediol pathway. Feeding with high-fat diet and HiAlc Kpn aggravated disease progression and severity, while glucose intake promoted detectable blood alcohol concentration, which represents a promising marker for clinical diagnosis. All these findings augmented our current knowledge of NAFLD.

Suggested Citation

Yuan, Jing and Wei, Xiao and Zhao, Xiangna and Chen, Chen and Lu, Jing and Cheng, Weiwei and Li, Boxin and Li, Huan and Lin, Weishi and Tian, Changyu and Zhao, Jiangtao and Han, Juqiang and An, Daizhi and Wei, Hong and Zheng, Minghua and Ma, Xuejun and Li, Wei and Wang, Xuesong and Chen, Xiao and Zhang, Zheng and Zeng, Hui and Ying, Sun and Wu, JianXin and Yang, Ruifu and Liu, Di, High Alcohol-Producing Klebsiella Pneumonia is a Bacterial Culprit of Fatty Liver Disease. Available at SSRN: https://ssrn.com/abstract=3376661 or http://dx.doi.org/10.2139/ssrn.3376661
This version of the paper has not been formally peer reviewed.

Jing Yuan (Contact Author)

Capital Institute of Pediatrics ( email )

Beijing, 10024
China

Xiao Wei

Academy of Military Sciences - Center for Disease Control and Prevention

China

Xiangna Zhao

Academy of Military Sciences - Center for Disease Control and Prevention

China

Chen Chen

Capital Medical University - Institute of Infectious Diseases

Beijing, 100015
China

Jing Lu

Capital Institute of Pediatrics

Beijing, 10024
China

Weiwei Cheng

Capital Institute of Pediatrics

Beijing, 10024
China

Boxin Li

Capital Institute of Pediatrics

Beijing, 10024
China

Huan Li

Academy of Military Sciences - Center for Disease Control and Prevention

China

Weishi Lin

Academy of Military Sciences - Center for Disease Control and Prevention

China

Changyu Tian

Academy of Military Sciences - Center for Disease Control and Prevention

China

Jiangtao Zhao

Academy of Military Sciences - Center for Disease Control and Prevention

China

Juqiang Han

PLA Army General Hospital - Institute of Hepatology

China

Daizhi An

Academy of Military Sciences - Center for Disease Control and Prevention

China

Hong Wei

Huazhong Agricultural University - The Engineering Technology Research Center for Germ-free and Genome-editing Animal

Wuhan, 430070
China

Minghua Zheng

Wenzhou Medical University - Department of Hepatology

China

Xuejun Ma

Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases - National Institute for Viral Disease Control and Prevention

China

Wei Li

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology

Jiangxia, Hubei
China

Xuesong Wang

Academy of Military Sciences - Center for Disease Control and Prevention

China

Xiao Chen

Capital Institute of Pediatrics

Beijing, 10024
China

Zheng Zhang

Capital Institute of Pediatrics

Beijing, 10024
China

Hui Zeng

Capital Medical University - Institute of Infectious Diseases

Beijing, 100015
China

Sun Ying

Capital Medical University - Department of Immunology

China

JianXin Wu

Capital Institute of Pediatrics

Beijing, 10024
China

Ruifu Yang

Academy of Military Sciences - Beijing Institute of Microbiology and Epidemiology

Beijing, 100071
China

Di Liu

Chinese Academy of Sciences (CAS) - Wuhan Institute of Virology ( email )

Jiangxia, Hubei
China

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