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Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

74 Pages Posted: 6 Aug 2018 Publication Status: Published

See all articles by Aude Nicolas

Aude Nicolas

Government of the United States of America - Neuromuscular Diseases Research Section

Kevin P. Kenna

University of Massachusetts Worcester - Department of Neurology

Alan E. Renton

Icahn School of Medicine at Mount Sinai - Nash Department of Neuroscience

Nicola Ticozzi

University of Milan - Department of Neurology and Laboratory of Neuroscience

Faraz Faghri

National Institutes of Health - Molecular Genetics Section

Ruth Chia

National Institutes of Health - Neuromuscular Diseases Research Section

Janice A. Dominov

University of Massachusetts Worcester - Department of Neurology

Brendan J. Kenna

University of Massachusetts Worcester - Department of Neurology

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Pamela Keagle

University of Massachusetts Worcester - Department of Neurology

Alberto M. Rivera

Government of the United States of America - Neuromuscular Diseases Research Section

Wouter van Rheenen

Utrecht University - Department of Neurology

Natalie A. Murphy

Government of the United States of America - Neuromuscular Diseases Research Section

Joke J.F.A. van Vugt

Utrecht University - Department of Neurology

Joshua T. Geiger

Government of the United States of America - Neurodegenerative Diseases Research Unit

Rick A. Van der Spek

Utrecht University - Department of Neurology

Hannah A. Pliner

National Institutes of Health - Neurodegenerative Diseases Research Unit

Bradley N. Smith

United Kingdom Dementia Research Institute Centre

Giuseppe Marangi

Government of the United States of America - Neuromuscular Diseases Research Section

Simon D. Topp

United Kingdom Dementia Research Institute Centre

Yevgeniya Abramzon

National Institutes of Health - Neuromuscular Diseases Research Section

Athina Soragia Gkazi

United Kingdom Dementia Research Institute Centre

John D. Eicher

Merck & Co., Inc. - Genetics and Pharmacogenomics

Aoife Kenna

University of Massachusetts Worcester - Department of Neurology

ITALSGEN Consortium

Independent

Gabriele Mora

Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center

Andrea Calvo

University of Turin - Department of Neurosciences

Letizia Mazzini

Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center

Nilo Riva

Università Vita-Salute San Raffaele - Department of Neurology

Jessica Mandrioli

Azienda Ospedaliero Universitaria di Modena - Department of Neuroscience

Claudia Caponnetto

Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ophthalmology, Genetics, Rehabilitation, Maternal and Child Health

Stefania Battistini

University of Siena - Department of Medical, Surgical and Neurological Sciences

Paolo Volanti

Salvatore Maugeri Foundation IRCCS - ALS Center

Vincenzo La Bella

University of Palermo - ALS Clinical Research Center

Francesca L. Conforti

University of Palermo - ALS Clinical Research Center

Giuseppe Borghero

Universita di Cagliari - Department of Neurology

Sonia Messina

University of Messina - Department of Clinical and Experimental Medicine

Isabella L. Simone

Università degli Studi di Bari “Aldo Moro” (UNIBA) - Department of Basic Medical Sciences, Neurosciences and Sense Organs

Francesca Trojsi

Università degli Studi della Campania - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences

Fabrizio Salvi

IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB) - Il Bene Center for Immunological and Rare Neurological Diseases

Francesco O. Logullo

Polytechnic University of Marche - Neurological Clinic

Sandra D’Alfonso

University of Eastern Piedmont - Department of Health Sciences

Lucia Corrado

University of Eastern Piedmont - Department of Health Sciences

Margherita Capasso

'Gabriele d'Annunzio' University of Chieti-Pescara - Department of Neurology

Luigi Ferrucci

Government of the United States of America - Longitudinal Studies Section

Genomic Translation for ALS Care (GTAC) Consortium

Independent

Cristiane de Araujo Martins Moreno

Columbia University Medical Center, Department of Neurology

Sitharthan Kamalakaran

Columbia University Medical Center, Department of Neurology

David B. Goldstein

Columbia University - Institute for Genomic Medicine

The ALS Sequencing Consortium

Independent

Aaron D. Gitler

Stanford University - Genetics Department

Tim Harris

Bioverativ

Richard M. Myers

HudsonAlpha Institute for Biotechnology

NYGC ALS Consortium

Independent

Hemali Phatnani

New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND); The NYGC ALS Consortium

Rajeeva Lochan Musunuri

New York Genome Center - Computational Biology

Uday Shankar Evani

New York Genome Center - Computational Biology

Avinash Abhyankar

New York Genome Center - Computational Biology

Michael Charles Zody

New York Genome Center - Computational Biology

Answer ALS Foundation

Independent

Julia Kaye

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

Steven Finkbeiner

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

Stacia Wyman

University of California, San Francisco (UCSF) - Gladstone Institutes

Alex Lenail

Massachusetts Institute of Technology (MIT) - Department of Biological Engineering

Leandro Lima

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

Ernest Fraenkel

Massachusetts Institute of Technology (MIT) - Department of Biological Engineering

Clive N. Svendsen

Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute

Leslie M. Thompson

University of California, Irvine - Department of Neurobiology and Behavior

Jennifer E. Van Eyk

Cedars Sinai Medical Center - Department of Medicine

James D. Berry

Harvard University - Department of Neurology

Timothy M. Miller

Washington University in St. Louis - Department of Neurology

Stephen J. Kolb

Ohio State University (OSU) - Department of Neurology

Merit Cudkowicz

Harvard University - Department of Neurology

Emily Baxi

Johns Hopkins University - Department of Neurology and Neurosurgery

Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium

Independent

Michael Benatar

University of Miami - Department of Neurology

J. Paul Taylor

Howard Hughes Medical Institute (HHMI) - Chevy Chase

Evadnie Rampersaud

St Jude Children’s Research Hospital - Department of Computational Biology

Gang Wu

St Jude Children’s Research Hospital - Department of Computational Biology

Joanne Wuu

University of Miami - Department of Neurology

SLAGEN Consortium

Independent

Giuseppe Lauria

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - 3rd Neurology Unit

Federico Verde

University of Milan - Department of Neurology

Isabella Fogh

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Cinzia Tiloca

University of Milan - Department of Neurology

Giacomo P. Comi

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Neurology Unit

Gianni Sorarù

University of Padua - Department of Neurosciences

Cristina Cereda

IRCCS ‘C. Mondino’ National Institute of Neurology Foundation - Experimental Neurobiology Laboratory

French ALS Consortium

Independent

Philippe Corcia

François Rabelais University - ALS Center

Hannu Laaksovirta

University of Helsinki - Molecular Neurology Programme

Liisa Myllykangas

University of Helsinki - Department of Pathology

Lilja Jansson

University of Helsinki - Molecular Neurology Programme

Miko Valori

University of Helsinki - Department of Neurology

John Ealing

Government of the United Kingdom - Department of Neurology

Hesham Hamdallah

Government of the United Kingdom - Department of Neurology

Sara Rollinson

The University of Manchester - Faculty of Human and Medical Sciences

Stuart Pickering-Brown

The University of Manchester - Faculty of Human and Medical Sciences

Richard W. Orrell

University College London - Department of Clinical Neuroscience

Katie C. Sidle

University College London - Department of Molecular Neuroscience

Andrea Malaspina

Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Wingate Institute of Neurogastroenterology, Centre for Neuroscience and Trauma

John Hardy

University College London - Department of Molecular Neuroscience

Andrew B. Singleton

Government of the United States of America - Laboratory of Neurogenetics; Government of the United States of America - Molecular Genetics Section

Janel O. Johnson

Government of the United States of America - Neuromuscular Diseases Research Section

Sampath Arepalli

Government of the United States of America - Genomics Technology Group

Peter C. Sapp

University of Massachusetts Worcester - Department of Neurology

Diane McKenna-Yasek

University of Massachusetts Worcester - Department of Neurology

Meraida Polak

Emory University - Department of Neurology

Seneshaw Asress

Emory University - Department of Neurology

Safa Al-Sarraj

United Kingdom Dementia Research Institute Centre

Andrew King

United Kingdom Dementia Research Institute Centre

Claire Troakes

United Kingdom Dementia Research Institute Centre

Caroline Vance

United Kingdom Dementia Research Institute Centre

Jacqueline de Belleroche

Imperial College London - Division of Brain Sciences

Frank Baas

University of Amsterdam - Department of Genome analysis and Neurogenetics

Anneloor LMA ten Asbroek

University of Amsterdam - Department of Neurogenetics and Neurology

José Luis Muñoz-Blanco

Gregorio Marañón Hospital - Unidad de ELA

Dena G. Hernandez

Government of the United States of America - Genomics Technology Group

Jinhui Ding

National Institutes of Health - Computational Biology Core

J. Raphael Gibbs

National Institutes of Health - Computational Biology Core

Sonja W. Scholz

National Institutes of Health - Neurodegenerative Diseases Research Unit

Mary Kay Floeter

Government of the United States of America - Motor Neuron Disorders Unit

Roy H. Campbell

University of Illinois at Urbana-Champaign - Department of Computer Science

Francesco Landi

Catholic University of Rome - Center for Geriatric Medicine

Stefan M. Pulst

University of Utah - Department of Neurology

John M. Ravits

University of California, San Diego (UCSD) - Department of Neurosciences

Daniel J. L. MacGowan

Mount Sinai Health System - Mount Sinai Beth Israel Hospital

Janine Kirby

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

Erik Pioro

Cleveland Clinic - Department of Neurology

Roger Pamphlett

The University of Sydney - Discipline of Pathology

James Broach

Pennsylvania State University - Department of Biochemistry

Glenn Gerhard

Pennsylvania State University - Department of Pathology

Travis L. Dunckley

Pennsylvania State University - Department of Pathology

Christopher B. Brady

Government of the United States of America - Research and Development Service

Neil W. Kowall

Government of the United States of America - Neurology Service

Juan Troncoso

Johns Hopkins University - Department of Pathology

Isabelle Le Ber

Sorbonne University - University Hospitals Pitié Salpêtrière - Charles Foix

Kevin Mouzat

UNIMES - Université de Nîmes - Department of Biochemistry

Serge Lumbroso

UNIMES - Université de Nîmes - Department of Biochemistry

Terry D. Heiman-Patterson

Temple University - Department of Neurology

Freya Kamel

Government of the United States of America - Epidemiology Branch

Ludo Van Den Bosch

KU Leuven - Division of Experimental Neurology

Robert H. Baloh

Cedars Sinai Medical Center - Department of Neurology

Tim M. Strom

Helmholtz Association of German Research Centres - Institute of Human Genetics

Thomas Meitinger

Technische Universität München (TUM) - Institute of Human Genetics

Aleksey Shatunov

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Kristel R. Van Eijk

Utrecht University - Department of Neurology

Mamede de Carvalho

University of Lisbon - Institute of Physiology

Maarten Kooyman

SURFsara

Bas Middelkoop

Utrecht University - Department of Neurology

Matthieu Moisse

KU Leuven - Division of Experimental Neurology

Russell L. McLaughlin

Trinity College (Dublin) - Population Genetics Laboratory

Michael A. Van Es

Utrecht University - Department of Neurology

Markus Weber

Kantonsspital St. Gallen - Neuromuscular Diseases Unit/ALS Clinic

Kevin B. Boylan

Mayo Clinic - Florida - Department of Neurology

Marka Van Blitterswijk

Mayo Clinic - Florida - Department of Neuroscience

Rosa Rademakers

Mayo Clinic - Florida - Department of Neuroscience

Karen E. Morrison

University of Southampton - Faculty of Medicine, Health and Life Sciences

A. Nazli Basak

Bogazici University - Suna and Inan Kırac Foundation

Jesús S. Mora

Hospital San Rafael - ALS Unit/Neurology

Vivian E. Drory

Tel Aviv Sourasky Medical Centre - Department of Neurology

Pamela J. Shaw

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

Martin R. Turner

University of Oxford - Nuffield Department of Clinical Neurosciences

Kevin Talbot

University of Oxford - Nuffield Department of Clinical Neurosciences

Orla Hardiman

Trinity College (Dublin) - Academic Unit of Neurology

Kelly L. Williams

Macquarie University - Centre for MND Research

Jennifer A. Fifita

Macquarie University - Centre for MND Research

Garth A. Nicholson

Macquarie University - Centre for MND Research

Ian P. Blair

Macquarie University - Centre for MND Research

Guy A. Rouleau

McGill University - Montreal Neurological Institute and Hospital

Jesús Esteban-Pérez

Gregorio Marañón Hospital - Unidad de ELA

Alberto García-Redondo

Gregorio Marañón Hospital - Unidad de ELA

Ammar Al-Chalabi

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Project MinE ALS Sequencing Consortium

Independent

Ekaterina Rogaeva

University of Toronto - Tanz Centre for Research of Neurodegenerative Diseases

Lorne Zinman

University of Toronto - Division of Neurology

Lyle Ostrow

Johns Hopkins University - Department of Neurology and Neurosurgery; The NYGC ALS Consortium

Nicholas J. Maragakis

Johns Hopkins University - Department of Neurology and Neurosurgery

Jeffrey D. Rothstein

Johns Hopkins University - Brain Science Institute

Zachary Simmons

Pennsylvania State University - Department of Neurology

Johnathan Cooper-Knock

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

Alexis Brice

Sorbonne University - University Hospitals Pitié Salpêtrière - Charles Foix

Stephen A. Goutman

University of Michigan at Ann Arbor - Department of Neurology

Eva L. Feldman

University of Michigan at Ann Arbor - Department of Neurology

Summer B. Gibson

University of Utah - Department of Neurology

Franco Taroni

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases

Antonia Ratti

University of Milan - Department of Pathophysiology and Transplantation

Cinzia Gellera

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases

Philip Van Damme

KU Leuven - Laboratory of Neurobiology

Wim Robberecht

KU Leuven - Laboratory of Neurobiology

Pietro Fratta

University College London - Sobell Department of Motor Neuroscience and Movement Disorders; University College London - Department of Neuromuscular Diseases

Mario Sabatelli

Catholic University of Rome - Institute of Neurology, Centro Clinico NeMO

Christian Lunetta

Serena Foundation Onlus - Clinical Center NEMO (NEuroMuscular Omnicenter)

Albert C. Ludolph

Ulm University - Department of Neurology

Peter M. Andersen

Umeå University - Department of Pharmacology and Clinical Neuroscience

Jochen H. Weishaupt

Ulm University - Department of Neurology

William Camu

University of Montpellier - ALS Center

John Q. Trojanowski

University of Pennsylvania - Department of Pathology and Lab Medicine

Vivianna M. Van Deerlin

University of Pennsylvania - Department of Pathology and Lab Medicine

Robert H. Brown

University of Massachusetts Worcester - Department of Neurology

Leonard H. van den Berg

Utrecht University - Department of Neurology

Jan H. Veldink

Utrecht University - Department of Neurology

Matthew B. Harms

Columbia University Medical Center, Department of Neurology

Jonathan D. Glass

Emory University - Department of Neurology

David J. Stone

University of Massachusetts Worcester - Department of Neurology

Pentti Tienari

University of Massachusetts Worcester - Department of Neurology

Vincenzo Silani

University of Massachusetts Worcester - Department of Neurology

Adriano Chiò

University of Massachusetts Worcester - Department of Neurology

Christopher E. Shaw

University of Massachusetts Worcester - Department of Neurology

Bryan J. Traynor

University of Massachusetts Worcester - Department of Neurology

John E. Landers

University of Massachusetts Worcester - Department of Neurology

More...

Abstract

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases, hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth Type 2 (CMT2). In contrast, ALS associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss of function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.

Suggested Citation

Nicolas, Aude and Kenna, Kevin P. and Renton, Alan E. and Ticozzi, Nicola and Faghri, Faraz and Chia, Ruth and Dominov, Janice A. and Kenna, Brendan J. and Nalls, Mike A. and Keagle, Pamela and Rivera, Alberto M. and Rheenen, Wouter van and Murphy, Natalie A. and Vugt, Joke J.F.A. van and Geiger, Joshua T. and Van der Spek, Rick A. and Pliner, Hannah A. and Smith, Bradley N. and Marangi, Giuseppe and Topp, Simon D. and Abramzon, Yevgeniya and Gkazi, Athina Soragia and Eicher, John D. and Kenna, Aoife and Consortium, ITALSGEN and Mora, Gabriele and Calvo, Andrea and Mazzini, Letizia and Riva, Nilo and Mandrioli, Jessica and Caponnetto, Claudia and Battistini, Stefania and Volanti, Paolo and Bella, Vincenzo La and Conforti, Francesca L. and Borghero, Giuseppe and Messina, Sonia and Simone, Isabella L. and Trojsi, Francesca and Salvi, Fabrizio and Logullo, Francesco O. and D’Alfonso, Sandra and Corrado, Lucia and Capasso, Margherita and Ferrucci, Luigi and (GTAC) Consortium, Genomic Translation for ALS Care and Martins Moreno, Cristiane de Araujo and Kamalakaran, Sitharthan and Goldstein, David B. and Consortium, The ALS Sequencing and Gitler, Aaron D. and Harris, Tim and Myers, Richard M. and Consortium, NYGC ALS and Phatnani, Hemali and Musunuri, Rajeeva Lochan and Evani, Uday Shankar and Abhyankar, Avinash and Zody, Michael Charles and Foundation, Answer ALS and Kaye, Julia and Finkbeiner, Steven and Wyman, Stacia and Lenail, Alex and Lima, Leandro and Fraenkel, Ernest and Svendsen, Clive N. and Thompson, Leslie M. and Van Eyk, Jennifer E. and Berry, James D. and Miller, Timothy M. and Kolb, Stephen J. and Cudkowicz, Merit and Baxi, Emily and Development (CReATe) Consortium, Clinical Research in ALS and Related Disorders for Therapeutic and Benatar, Michael and Taylor, J. Paul and Rampersaud, Evadnie and Wu, Gang and Wuu, Joanne and Consortium, SLAGEN and Lauria, Giuseppe and Verde, Federico and Fogh, Isabella and Tiloca, Cinzia and Comi, Giacomo P. and Sorarù, Gianni and Cereda, Cristina and Consortium, French ALS and Corcia, Philippe and Laaksovirta, Hannu and Myllykangas, Liisa and Jansson, Lilja and Valori, Miko and Ealing, John and Hamdallah, Hesham and Rollinson, Sara and Pickering-Brown, Stuart and Orrell, Richard W. and Sidle, Katie C. and Malaspina, Andrea and Hardy, John and Singleton, Andrew B. and Johnson, Janel O. and Arepalli, Sampath and Sapp, Peter C. and McKenna-Yasek, Diane and Polak, Meraida and Asress, Seneshaw and Al-Sarraj, Safa and King, Andrew and Troakes, Claire and Vance, Caroline and Belleroche, Jacqueline de and Baas, Frank and Asbroek, Anneloor LMA ten and Muñoz-Blanco, José Luis and Hernandez, Dena G. and Ding, Jinhui and Gibbs, J. Raphael and Scholz, Sonja W. and Floeter, Mary Kay and Campbell, Roy H. and Landi, Francesco and Pulst, Stefan M. and Ravits, John M. and MacGowan, Daniel J. L. and Kirby, Janine and Pioro, Erik and Pamphlett, Roger and Broach, James and Gerhard, Glenn and Dunckley, Travis L. and Brady, Christopher B. and Kowall, Neil W. and Troncoso, Juan and Le Ber, Isabelle and Mouzat, Kevin and Lumbroso, Serge and Heiman-Patterson, Terry D. and Kamel, Freya and Bosch, Ludo Van Den and Baloh, Robert H. and Strom, Tim M. and Meitinger, Thomas and Shatunov, Aleksey and Van Eijk, Kristel R. and de Carvalho, Mamede and Kooyman, Maarten and Middelkoop, Bas and Moisse, Matthieu and McLaughlin, Russell L. and Van Es, Michael A. and Weber, Markus and Boylan, Kevin B. and Van Blitterswijk, Marka and Rademakers, Rosa and Morrison, Karen E. and Basak, A. Nazli and Mora, Jesús S. and Drory, Vivian E. and Shaw, Pamela J. and Turner, Martin R. and Talbot, Kevin and Hardiman, Orla and Williams, Kelly L. and Fifita, Jennifer A. and Nicholson, Garth A. and Blair, Ian P. and Rouleau, Guy A. and Esteban-Pérez, Jesús and García-Redondo, Alberto and Al-Chalabi, Ammar and , Project MinE ALS Sequencing Consortium and Rogaeva, Ekaterina and Zinman, Lorne and Ostrow, Lyle and Maragakis, Nicholas J. and Rothstein, Jeffrey D. and Simmons, Zachary and Cooper-Knock, Johnathan and Brice, Alexis and Goutman, Stephen A. and Feldman, Eva L. and Gibson, Summer B. and Taroni, Franco and Ratti, Antonia and Gellera, Cinzia and Van Damme, Philip and Robberecht, Wim and Fratta, Pietro and Sabatelli, Mario and Lunetta, Christian and Ludolph, Albert C. and Andersen, Peter M. and Weishaupt, Jochen H. and Camu, William and Trojanowski, John Q. and Van Deerlin, Vivianna M. and Brown, Robert H. and van den Berg, Leonard H. and Veldink, Jan H. and Harms, Matthew B. and Glass, Jonathan D. and Stone, David J. and Tienari, Pentti and Silani, Vincenzo and Chiò, Adriano and Shaw, Christopher E. and Traynor, Bryan J. and Landers, John E., Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene (April 3, 2018). Available at SSRN: https://ssrn.com/abstract=3155776 or http://dx.doi.org/10.2139/ssrn.3155776
This version of the paper has not been formally peer reviewed.

Aude Nicolas (Contact Author)

Government of the United States of America - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Kevin P. Kenna

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Alan E. Renton

Icahn School of Medicine at Mount Sinai - Nash Department of Neuroscience

New York, NY 10029
United States

Nicola Ticozzi

University of Milan - Department of Neurology and Laboratory of Neuroscience

Milan
Italy

Faraz Faghri

National Institutes of Health - Molecular Genetics Section

Bethseda, MD 20892
United States

Ruth Chia

National Institutes of Health - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Janice A. Dominov

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Brendan J. Kenna

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Bethseda, MD 20892
United States

Pamela Keagle

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Alberto M. Rivera

Government of the United States of America - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Wouter van Rheenen

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Natalie A. Murphy

Government of the United States of America - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Joke J.F.A. van Vugt

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Joshua T. Geiger

Government of the United States of America - Neurodegenerative Diseases Research Unit

Bethesda, MD
United States

Rick A. Van der Spek

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Hannah A. Pliner

National Institutes of Health - Neurodegenerative Diseases Research Unit

Bethesda, MD 20892
United States

Bradley N. Smith

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Giuseppe Marangi

Government of the United States of America - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Simon D. Topp

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Yevgeniya Abramzon

National Institutes of Health - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Athina Soragia Gkazi

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

John D. Eicher

Merck & Co., Inc. - Genetics and Pharmacogenomics

West Point, PA 19486
United States

Aoife Kenna

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

ITALSGEN Consortium

Independent

Gabriele Mora

Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center

Novara
Italy

Andrea Calvo

University of Turin - Department of Neurosciences

Via Verdi, 8
Torino, 10124
Italy

Letizia Mazzini

Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center

Novara
Italy

Nilo Riva

Università Vita-Salute San Raffaele - Department of Neurology

Milan
Italy

Jessica Mandrioli

Azienda Ospedaliero Universitaria di Modena - Department of Neuroscience

Modena
Italy

Claudia Caponnetto

Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ophthalmology, Genetics, Rehabilitation, Maternal and Child Health

Genoa
Italy

Stefania Battistini

University of Siena - Department of Medical, Surgical and Neurological Sciences

Via Banchi di Sotto, 55
Siena, 53100
Italy

Paolo Volanti

Salvatore Maugeri Foundation IRCCS - ALS Center

Italy

Vincenzo La Bella

University of Palermo - ALS Clinical Research Center

Viale delle Scienza
Palermo, Buenos Aires 90100
Italy

Francesca L. Conforti

University of Palermo - ALS Clinical Research Center

Viale delle Scienza
Palermo, Buenos Aires 90100
Italy

Giuseppe Borghero

Universita di Cagliari - Department of Neurology

Cagliari, 09124
Italy

Sonia Messina

University of Messina - Department of Clinical and Experimental Medicine

Messina
Italy

Isabella L. Simone

Università degli Studi di Bari “Aldo Moro” (UNIBA) - Department of Basic Medical Sciences, Neurosciences and Sense Organs

Italy

Francesca Trojsi

Università degli Studi della Campania - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences

Naples
Italy

Fabrizio Salvi

IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB) - Il Bene Center for Immunological and Rare Neurological Diseases

Via Altura, 3
Padiglione G
Bologna BO, 40139
Italy

Francesco O. Logullo

Polytechnic University of Marche - Neurological Clinic

Ancona
Italy

Sandra D’Alfonso

University of Eastern Piedmont - Department of Health Sciences

Novara
Italy

Lucia Corrado

University of Eastern Piedmont - Department of Health Sciences

Novara
Italy

Margherita Capasso

'Gabriele d'Annunzio' University of Chieti-Pescara - Department of Neurology

Chieti
Italy

Luigi Ferrucci

Government of the United States of America - Longitudinal Studies Section

Baltimore, MD 21224
United States

Cristiane de Araujo Martins Moreno

Columbia University Medical Center, Department of Neurology

College of Physicians and Surgeons
630 West 168th Street, 3rd Floor, Suite 3-470
New York, NY 10032-3784
United States

Sitharthan Kamalakaran

Columbia University Medical Center, Department of Neurology

College of Physicians and Surgeons
630 West 168th Street, 3rd Floor, Suite 3-470
New York, NY 10032-3784
United States

David B. Goldstein

Columbia University - Institute for Genomic Medicine

701 West 168th St.
Hammer Health Sciences, 1408
New York, NY 10032
United States

Aaron D. Gitler

Stanford University - Genetics Department ( email )

Tim Harris

Bioverativ

225 2nd Ave
Waltham, MA 02145
United States

Richard M. Myers

HudsonAlpha Institute for Biotechnology

Huntsville, AL 35806
United States

NYGC ALS Consortium

Independent

Hemali Phatnani

New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND)

New York, NY
United States

The NYGC ALS Consortium

United States

Rajeeva Lochan Musunuri

New York Genome Center - Computational Biology

New York, NY
United States

Uday Shankar Evani

New York Genome Center - Computational Biology

New York, NY
United States

Avinash Abhyankar

New York Genome Center - Computational Biology

New York, NY
United States

Michael Charles Zody

New York Genome Center - Computational Biology

New York, NY
United States

Answer ALS Foundation

Independent

Julia Kaye

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

San Francisco, CA
United States

Steven Finkbeiner

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

San Francisco, CA
United States

Stacia Wyman

University of California, San Francisco (UCSF) - Gladstone Institutes

1650 Owens St.
San Francisco, CA 94158
United States

Alex Lenail

Massachusetts Institute of Technology (MIT) - Department of Biological Engineering

77 Massachusetts Avenue
50 Memorial Drive
Cambridge, MA 02139-4307
United States

Leandro Lima

University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease

San Francisco, CA
United States

Ernest Fraenkel

Massachusetts Institute of Technology (MIT) - Department of Biological Engineering ( email )

77 Massachusetts Avenue
50 Memorial Drive
Cambridge, MA 02139-4307
United States

Clive N. Svendsen

Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute

8700 Beverly Blvd.
Los Angeles, CA
United States

Leslie M. Thompson

University of California, Irvine - Department of Neurobiology and Behavior

CA 92697
United States

Jennifer E. Van Eyk

Cedars Sinai Medical Center - Department of Medicine

8700 Beverly Blvd.
Los Angeles, CA
United States

James D. Berry

Harvard University - Department of Neurology

Boston, MA
United States

Timothy M. Miller

Washington University in St. Louis - Department of Neurology

St. Louis, MO
United States

Stephen J. Kolb

Ohio State University (OSU) - Department of Neurology

Colombus, OH
United States

Merit Cudkowicz

Harvard University - Department of Neurology

Boston, MA
United States

Emily Baxi

Johns Hopkins University - Department of Neurology and Neurosurgery

1800 Orleans St.
Baltimore, MD 21287
United States

Michael Benatar

University of Miami - Department of Neurology

Miami, FL
United States

J. Paul Taylor

Howard Hughes Medical Institute (HHMI) - Chevy Chase

4000 Jones Bridge Road
Chevy Chase, MD 20815-6789
United States

Evadnie Rampersaud

St Jude Children’s Research Hospital - Department of Computational Biology

Memphis, TN 38105
United States

Gang Wu

St Jude Children’s Research Hospital - Department of Computational Biology

Memphis, TN 38105
United States

Joanne Wuu

University of Miami - Department of Neurology

Miami, FL
United States

SLAGEN Consortium

Independent

Giuseppe Lauria

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - 3rd Neurology Unit

Via Celoria 11
Milan, 20133
Italy

Federico Verde

University of Milan - Department of Neurology

Via Pellizza da Volpedo, 41
Milano, 20149
Italy

Isabella Fogh

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Strand
London, England WC2R 2LS
United Kingdom

Cinzia Tiloca

University of Milan - Department of Neurology

Via Pellizza da Volpedo, 41
Milano, 20149
Italy

Giacomo P. Comi

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Neurology Unit

Via Manfredo Fanti, 6
Milano MI, 20122
Italy

Gianni Sorarù

University of Padua - Department of Neurosciences

Via 8 Febbraio, 2
Padova, 35122
Italy

Cristina Cereda

IRCCS ‘C. Mondino’ National Institute of Neurology Foundation - Experimental Neurobiology Laboratory

Mondino 2
Pavia, 27100
Italy

French ALS Consortium

Independent

Philippe Corcia

François Rabelais University - ALS Center

2 Boulevard Tonnellé
Tours, 37000
France

Hannu Laaksovirta

University of Helsinki - Molecular Neurology Programme

Helsinki, FIN-00014
Finland

Liisa Myllykangas

University of Helsinki - Department of Pathology

Helsinki, FIN-00014
Finland

Lilja Jansson

University of Helsinki - Molecular Neurology Programme

Helsinki, FIN-00014
Finland

Miko Valori

University of Helsinki - Department of Neurology

Topeliuksenkatu 5
Helsinki, 00260
United States

John Ealing

Government of the United Kingdom - Department of Neurology

Stott Ln
Salford M6 8HD
United Kingdom

Hesham Hamdallah

Government of the United Kingdom - Department of Neurology

Stott Ln
Salford M6 8HD
United Kingdom

Sara Rollinson

The University of Manchester - Faculty of Human and Medical Sciences

United Kingdom

Stuart Pickering-Brown

The University of Manchester - Faculty of Human and Medical Sciences

United Kingdom

Richard W. Orrell

University College London - Department of Clinical Neuroscience

Queen Square
London WC1N
United Kingdom

Katie C. Sidle

University College London - Department of Molecular Neuroscience

Gower Street
London, WC1E 6BT
United Kingdom

Andrea Malaspina

Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Wingate Institute of Neurogastroenterology, Centre for Neuroscience and Trauma

Mile End Rd
London, E1 4NS
United Kingdom

John Hardy

University College London - Department of Molecular Neuroscience

Gower Street
London, WC1E 6BT
United Kingdom

Andrew B. Singleton

Government of the United States of America - Laboratory of Neurogenetics

Bethesda, MD 20892
United States

Government of the United States of America - Molecular Genetics Section

Bethseda, MD 20892
United States

Janel O. Johnson

Government of the United States of America - Neuromuscular Diseases Research Section

Bethesda, MD 20892
United States

Sampath Arepalli

Government of the United States of America - Genomics Technology Group

Building 31, Room 5C27
31 Center Drive, MSC 2292
Bethesda, MD 20892
United States

Peter C. Sapp

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Diane McKenna-Yasek

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Meraida Polak

Emory University - Department of Neurology

1648 Pierce Dr NE
Atlanta, GA 30322
United States

Seneshaw Asress

Emory University - Department of Neurology

1648 Pierce Dr NE
Atlanta, GA 30322
United States

Safa Al-Sarraj

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Andrew King

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Claire Troakes

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Caroline Vance

United Kingdom Dementia Research Institute Centre

Gower Street
London, WC1E 6BT
United Kingdom

Jacqueline de Belleroche

Imperial College London - Division of Brain Sciences

South Kensington Campus
Exhibition Road
London, Greater London SW7 2AZ
United Kingdom

Frank Baas

University of Amsterdam - Department of Genome analysis and Neurogenetics

Amsterdam
Netherlands

Anneloor LMA ten Asbroek

University of Amsterdam - Department of Neurogenetics and Neurology

Netherlands

José Luis Muñoz-Blanco

Gregorio Marañón Hospital - Unidad de ELA

Calle del Dr. Esquerdo, 46
Madrid, 28007
Spain

Dena G. Hernandez

Government of the United States of America - Genomics Technology Group

Building 31, Room 5C27
31 Center Drive, MSC 2292
Bethesda, MD 20892
United States

Jinhui Ding

National Institutes of Health - Computational Biology Core

Building 31, Room 5C27
31 Center Drive, MSC 2292
Bethesda, MD 20892
United States

J. Raphael Gibbs

National Institutes of Health - Computational Biology Core

Building 31, Room 5C27
31 Center Drive, MSC 2292
Bethesda, MD 20892
United States

Sonja W. Scholz

National Institutes of Health - Neurodegenerative Diseases Research Unit

Bethesda, MD
United States

Mary Kay Floeter

Government of the United States of America - Motor Neuron Disorders Unit

9000 Rockville Pike
Bethesda, MD 20892
United States

Roy H. Campbell

University of Illinois at Urbana-Champaign - Department of Computer Science

Urbana, IL
United States

Francesco Landi

Catholic University of Rome - Center for Geriatric Medicine

Rome
Italy

Stefan M. Pulst

University of Utah - Department of Neurology

175 North Medical Drive East
Salt Lake City,, UT 84132
United States

John M. Ravits

University of California, San Diego (UCSD) - Department of Neurosciences

9500 Gilman Dr.
La Jolla, CA 92093
United States

Daniel J. L. MacGowan

Mount Sinai Health System - Mount Sinai Beth Israel Hospital

281 1st Avenue
New York, NY 10003
United States

Janine Kirby

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

385a Glossop Road
Sheffield
United Kingdom

Erik Pioro

Cleveland Clinic - Department of Neurology

6770 Mayfield Rd # 226
Cleveland, OH 44124
United States

Roger Pamphlett

The University of Sydney - Discipline of Pathology

Sydney, New South Wales NSW 2006
Australia

James Broach

Pennsylvania State University - Department of Biochemistry

700 HMC Crescent Road Hershey
Hershey, PA 17033
United States

Glenn Gerhard

Pennsylvania State University - Department of Pathology

700 HMC Crescent Road Hershey
Hershey, PA 17033
United States

Travis L. Dunckley

Pennsylvania State University - Department of Pathology

700 HMC Crescent Road Hershey
Hershey, PA 17033
United States

Christopher B. Brady

Government of the United States of America - Research and Development Service

150 S Huntington Ave.
Boston, MA 02130
United States

Neil W. Kowall

Government of the United States of America - Neurology Service

150 S Huntington Ave.
Boston, MA 02130
United States

Juan Troncoso

Johns Hopkins University - Department of Pathology

Baltimore, MD 21231
United States

Isabelle Le Ber

Sorbonne University - University Hospitals Pitié Salpêtrière - Charles Foix

175 Rue du Chevaleret
Paris, 75013
France

Kevin Mouzat

UNIMES - Université de Nîmes - Department of Biochemistry

Place du Pr R. Debré
CEDEX 9
Nîmes, 30029
France

Serge Lumbroso

UNIMES - Université de Nîmes - Department of Biochemistry

Place du Pr R. Debré
CEDEX 9
Nîmes, 30029
France

Terry D. Heiman-Patterson

Temple University - Department of Neurology

Medicine Education & Research Building
3500 N. Broad St.
Philadelphia, PA 19140
United States

Freya Kamel

Government of the United States of America - Epidemiology Branch

111 T.W. Alexander Drive
Durham, NC 27709
United States

Ludo Van Den Bosch

KU Leuven - Division of Experimental Neurology

Oude Markt 13 - bus 5005
Leuven, 3000
Belgium

Robert H. Baloh

Cedars Sinai Medical Center - Department of Neurology

127 S. San Vicente Blvd.
Advanced Health Sciences Pavilion, Sixth Floor, A6
Los Angeles, CA 90048
United States

Tim M. Strom

Helmholtz Association of German Research Centres - Institute of Human Genetics

Berlin Office
Anna-Louisa-Karsch-Straße 2
Berlin, DE 10178
Germany

Thomas Meitinger

Technische Universität München (TUM) - Institute of Human Genetics

Arcisstrasse 21
Munich, 80333
Germany

Aleksey Shatunov

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Strand
London, England WC2R 2LS
United Kingdom

Kristel R. Van Eijk

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Mamede De Carvalho

University of Lisbon - Institute of Physiology

R. Branca Edmée Marques
Lisboa, 1600-276
Portugal

Maarten Kooyman

SURFsara

Amsterdam
Netherlands

Bas Middelkoop

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Matthieu Moisse

KU Leuven - Division of Experimental Neurology

Oude Markt 13 - bus 5005
Leuven, 3000
Belgium

Russell L. McLaughlin

Trinity College (Dublin) - Population Genetics Laboratory

2-3 College Green
Dublin, Leinster
Ireland

Michael A. Van Es

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Markus Weber

Kantonsspital St. Gallen - Neuromuscular Diseases Unit/ALS Clinic

Rorschacher Str. 95
St. Gallen, 9007
Switzerland

Kevin B. Boylan

Mayo Clinic - Florida - Department of Neurology

4500 San Pablo Rd S
Jacksonville, 32224
United States

Marka Van Blitterswijk

Mayo Clinic - Florida - Department of Neuroscience

4500 San Pablo Rd S
Jacksonville, 32224
United States

Rosa Rademakers

Mayo Clinic - Florida - Department of Neuroscience

4500 San Pablo Rd S
Jacksonville, 32224
United States

Karen E. Morrison

University of Southampton - Faculty of Medicine, Health and Life Sciences

Southampton
United Kingdom

A. Nazli Basak

Bogazici University - Suna and Inan Kırac Foundation

Bebek, İstanbul 34342
Turkey

Jesús S. Mora

Hospital San Rafael - ALS Unit/Neurology

Calle de Serrano
199, 28016
Madrid, Community of Madrid
Spain

Vivian E. Drory

Tel Aviv Sourasky Medical Centre - Department of Neurology

Weizmann St 6
Tel Aviv-Yafo
Israel

Pamela J. Shaw

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

385a Glossop Road
Sheffield
United Kingdom

Martin R. Turner

University of Oxford - Nuffield Department of Clinical Neurosciences

Oxford
United Kingdom

Kevin Talbot

University of Oxford - Nuffield Department of Clinical Neurosciences ( email )

Oxford
United Kingdom

Orla Hardiman

Trinity College (Dublin) - Academic Unit of Neurology ( email )

Trinity College Dublin
52 - 160 Pearse St
Ireland

Kelly L. Williams

Macquarie University - Centre for MND Research

NSW 2109
Australia

Jennifer A. Fifita

Macquarie University - Centre for MND Research

NSW 2109
Australia

Garth A. Nicholson

Macquarie University - Centre for MND Research

NSW 2109
Australia

Ian P. Blair

Macquarie University - Centre for MND Research

NSW 2109
Australia

Guy A. Rouleau

McGill University - Montreal Neurological Institute and Hospital

3801 University Street
Montreal, Quebec H3A 2B4
Canada

Jesús Esteban-Pérez

Gregorio Marañón Hospital - Unidad de ELA

Calle del Dr. Esquerdo, 46
Madrid, 28007
Spain

Alberto García-Redondo

Gregorio Marañón Hospital - Unidad de ELA

Calle del Dr. Esquerdo, 46
Madrid, 28007
Spain

Ammar Al-Chalabi

King’s College London - Maurice Wohl Clinical Neuroscience Institute

Strand
London, England WC2R 2LS
United Kingdom

Ekaterina Rogaeva

University of Toronto - Tanz Centre for Research of Neurodegenerative Diseases

Toronto, Ontario M5S 3H2
Canada

Lorne Zinman

University of Toronto - Division of Neurology

Toronto, Ontario M5S 3H2
Canada

Lyle Ostrow

Johns Hopkins University - Department of Neurology and Neurosurgery

Baltimore, MD 21205
United States

The NYGC ALS Consortium

United States

Nicholas J. Maragakis

Johns Hopkins University - Department of Neurology and Neurosurgery

Baltimore, MD 21205
United States

Jeffrey D. Rothstein

Johns Hopkins University - Brain Science Institute

Baltimore, MD 21205
United States

Zachary Simmons

Pennsylvania State University - Department of Neurology

500 University Dr
Hershey, PA 17033
United States

Johnathan Cooper-Knock

University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)

385a Glossop Road
Sheffield
United Kingdom

Alexis Brice

Sorbonne University - University Hospitals Pitié Salpêtrière - Charles Foix

175 Rue du Chevaleret
Paris, 75013
France

Stephen A. Goutman

University of Michigan at Ann Arbor - Department of Neurology

Ann Arbor, MI 48109
United States

Eva L. Feldman

University of Michigan at Ann Arbor - Department of Neurology

Ann Arbor, MI 48109
United States

Summer B. Gibson

University of Utah - Department of Neurology

175 North Medical Drive East
Salt Lake City,, UT 84132
United States

Franco Taroni

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases

Milan, 20133
Italy

Antonia Ratti

University of Milan - Department of Pathophysiology and Transplantation

Milan, 20122
Italy

Cinzia Gellera

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases

Milan, 20133
Italy

Philip Van Damme

KU Leuven - Laboratory of Neurobiology

Oude Markt 13
Leuven, Vlaams-Brabant 3000
Belgium

Wim Robberecht

KU Leuven - Laboratory of Neurobiology

Oude Markt 13
Leuven, Vlaams-Brabant 3000
Belgium

Pietro Fratta

University College London - Sobell Department of Motor Neuroscience and Movement Disorders

London
United Kingdom

University College London - Department of Neuromuscular Diseases

United Kingdom

Mario Sabatelli

Catholic University of Rome - Institute of Neurology, Centro Clinico NeMO

Milano
Italy

Christian Lunetta

Serena Foundation Onlus - Clinical Center NEMO (NEuroMuscular Omnicenter)

Piazza Ospedale Maggiore 3
area sud padiglione 7a II piano
Milan, MI 20162
Italy

Albert C. Ludolph

Ulm University - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

Peter M. Andersen

Umeå University - Department of Pharmacology and Clinical Neuroscience

University Hospital of Umeå
Building 6B, 2nd floor
Umeå, SE-90187
Sweden

Jochen H. Weishaupt

Ulm University - Department of Neurology

Albert-Einstein-Alee 11
Ulm, D-89081
Germany

William Camu

University of Montpellier - ALS Center

University Hospital Center from Montpellier
191 avenue du Doyen Gaston Giraud
Montpellier
France

John Q. Trojanowski

University of Pennsylvania - Department of Pathology and Lab Medicine

3400 Spruce St.
Philadelphia, PA 19104-4238
United States

Vivianna M. Van Deerlin

University of Pennsylvania - Department of Pathology and Lab Medicine

3400 Spruce St.
Philadelphia, PA 19104-4238
United States

Robert H. Brown

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Leonard H. Van den Berg

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Jan H. Veldink

Utrecht University - Department of Neurology

GA Utrecht
Netherlands

Matthew B. Harms

Columbia University Medical Center, Department of Neurology

College of Physicians and Surgeons
630 West 168th Street, 3rd Floor, Suite 3-470
New York, NY 10032-3784
United States

Jonathan D. Glass

Emory University - Department of Neurology

1648 Pierce Dr NE
Atlanta, GA 30322
United States

David J. Stone

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Pentti Tienari

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Vincenzo Silani

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Adriano Chiò

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Christopher E. Shaw

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

Bryan J. Traynor

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

John E. Landers

University of Massachusetts Worcester - Department of Neurology

Worcester, MA
United States

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