See all articles by Julia M. GauglitzUniversity of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
San Diego Zoo Global - Reproductive Sciences
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Department of Bioengineering
University of California, San Diego (UCSD) - Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California, San Diego (UCSD) - Center for Microbiome Innovation
University of California, San Diego (UCSD) - Department of Pediatrics
UCSD School of Medicine - Division of Rheumatology, Allergy and Immunology
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of Minnesota - St. Paul - BioTechnology Institute
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Department of Computer Science & Engineering
University of California, San Diego (UCSD) - Department of Pediatrics
University of Colorado at Boulder - Department of Integrative Physiology
Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales Simón Bolívar
University of Colorado at Boulder - Department of Integrative Physiology
University of California, San Diego (UCSD) - Department of Pediatrics
Wake Forest School of Medicine - Department of Pediatrics
Michigan State University - Department of Animal Science
University of São Paulo (USP) - Department of Pharmacology
Federal University of Bahia (UFBA) - Multidisciplinary Health Institute
University of São Paulo (USP) - NPPNS
University of São Paulo (USP) - Department of Pharmacology
University of São Paulo (USP) - Department of Pharmacology
University of São Paulo (USP) - Department of Internal Medicine
University of São Paulo (USP) - Ribeirão Preto Medical School
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
University of California, San Diego (UCSD) - Department of Neurology
University of California, San Diego (UCSD) - Division of Gastroenterology
The Scripps Research Institute - Department of Molecular Medicine
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center
UCSD School of Medicine - Division of Rheumatology, Allergy and Immunology
University of California, San Diego (UCSD) - Department of Pediatrics
University of Cincinnati - Division of Neonatology
University of California, San Diego (UCSD) - Department of Pediatrics
University of California, San Diego (UCSD) - Division of Pediatric Hospital Medicine
University of Colorado at Boulder - Department of Integrative Physiology
Rutgers, The State University of New Jersey - Department of Biochemistry and Microbiology
Washington University in St. Louis - Department of Pediatrics
University of California, San Diego (UCSD) - Department of Medicine
University of California, San Diego (UCSD) - Department of Neurosciences
University of São Paulo (USP) - NPPNS
University of California, San Diego (UCSD) - Department of Cellular & Molecular Medicine
University of California, San Diego (UCSD) - Center for Microbiome Innovation
University of California, San Diego (UCSD) - Division of Biological Sciences
University of California, San Diego (UCSD) - Department of Computer Science & Engineering; University of California, San Diego (UCSD) - Department of Pediatrics; University of California, San Diego (UCSD) - Center for Microbiome Innovation
University of California, San Diego (UCSD) - Collaborative Mass Spectrometry Innovation Center; University of California, San Diego (UCSD) - Department of Computer Science & Engineering; University of California, San Diego (UCSD) - Department of Pediatrics; University of California, San Diego (UCSD) - Center for Microbiome Innovation; University of California, San Diego (UCSD) - Skaggs School of Pharmacy and Pharmaceutical Sciences
Abstract
The human metabolome has remained largely unknown, with most studies annotating ~10% of features. In nucleic acid sequencing, annotating transcripts by source has proven essential for understanding gene function. Here we generalize this concept to stool, plasma, urine and other human metabolomes, discovering that food-based annotations increase the interpreted fraction of molecular features 7-fold, providing a general framework for expanding the interpretability of human metabolomic “dark matter.”
Gauglitz, Julia M. and Bittremieux, Wout and Williams, Candace L. and Weldon, Kelly C. and Panitchpakdi, Morgan W. and Di Ottavio, Francesca and Aceves, Christine M. and Brown, Elizabeth and Sikora, Nicole C. and Jarmusch, Alan K. and Martino, Cameron and Tripathi, Anupriya and Sayyari, Erfan and Shaffer, Justin and Coras, Roxana and Vargas, Fernando and DeRight Goldasich, Lindsay and Schwartz, Tara and Bryant, MacKenzie and Humphrey, Gregory and Johnson, Abigail J. and Spengler, Katharina and Belda-Ferre, Pedro and Diaz, Edgar and McDonald, Daniel and Zhu, Qiyun and Nguyen, Dominic S. and Elijah, Emmanuel O. and Wang, Mingxun and Marotz, Clarisse and Sprecher, Kate E. and Vargas-Robles, Daniela and Withrow, Dana and Ackermann, Gail and Herrera, Lourdes and Bradford, Barry J. and Marques, Lucas Maciel Mauriz and Amaral, Juliano Geraldo and Silva, Rodrigo Moreira and Veras, Flávio Protaso and Cunha, Thiago Mattar and Oliveira, Rene Donizeti Ribeiro and Louzada-Junior, Paulo and Mills, Robert H. and Galasko, Douglas and Dulai, Parambir S. and Wittenberg, Curt and Gonzalez, David J. and Terkeltaub, Robert and Doty, Megan M. and Kim, Jae H. and Rhee, Kyung E. and Beauchamp-Walters, Julia and Wright Jr, Kenneth P. and Dominguez Bello, Maria Gloria and Manary, Mark and Oliveira, Michelli F. and Boland, Brigid S. and Lopes, Norberto Peporine and Guma, Monica and Swafford, Austin D. and Dutton, Rachel and Knight, Rob and Dorrestein, Pieter, Reference Data Based Insights Expand Understanding of Human Metabolomes. Available at SSRN:
https://ssrn.com/abstract=3661950 or
http://dx.doi.org/10.2139/ssrn.3661950
Download This Paper