Search Results
MedRN: Amyotrophic Lateral Sclerosis (Topic)

314 Total downloads

Viewing: 1 - 23 of 23 papers

1.

Motor Neuron Disease-Associated Loss of Nuclear TDP-43 Is Linked to DNA Double-Strand Break Repair Defects

Number of pages: 60 Posted: 12 Apr 2018
Working Paper Series
Houston Methodist Research Institute - Department of Radiation Oncology, Houston Methodist Research Institute - Department of Radiation Oncology, Houston Methodist Research Institute - Department of Radiation Oncology, VA Puget Sound Health Care System - Geriatric Research Education and Clinical Center, Houston Methodist Research Institute - Department of Radiation Oncology, Houston Methodist Research Institute - Department of Radiation Oncology, University of Texas Medical Branch-Galveston - Department of Neuroscience, Cell Biology, and Anatomy, Houston Methodist Research Institute - Department of Radiation Oncology, St Jude Children’s Research Hospital - Department of Cell and Molecular Biology, VA Puget Sound Health Care System - Geriatric Research Education and Clinical Center, University of Texas Medical Branch-Galveston - Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch-Galveston - Department of Microbiology and Immunology, State University of New York (SUNY) - Department of Anthropology, Houston Methodist Research Institute - Department of Radiation Oncology, Institute of Scientific Research and High Technology Services (INDICASAT AIP) - Center for Neuroscience and Houston Methodist Research Institute - Department of Radiation Oncology
Downloads 52
2.

Safety and Tolerability of Triumeq in Amyotrophic Lateral Sclerosis: The Lighthouse Trial

Number of pages: 30 Posted: 08 Mar 2019
Working Paper Series
The University of Sydney - The Albion Centre, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 34
3.

Mutations in the Glycosyltransferase Domain of GLT8D1 Cause Amyotrophic Lateral Sclerosis

Number of pages: 37 Posted: 10 Sep 2018
Working Paper Series
University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), KU Leuven - VIB & KU Leuven Center for Brain & Disease Research, KU Leuven - Laboratory of Neurobiology, KU Leuven - Laboratory of Neurobiology, Trinity College (Dublin) - Academic Unit of Neurology, University Hospital of Bellvitge, Hospital San Rafael - ALS Unit/Neurology, Bogazici University - Suna and Inan K?rac Foundation, University of Southampton - Faculty of Medicine, Health and Life Sciences, University of Massachusetts Worcester - Department of Neurology, University of London - Maurice Wohl Clinical Neuroscience Institute, University of Massachusetts Worcester - Department of Neurology, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN) and University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN)
Downloads 29
4.

Amyotrophic Lateral Sclerosis EEG Classification using Deep Neural Network and TLBO

Number of pages: 7 Posted: 01 Apr 2020
Working Paper Series
School of Computer Science & Information Technology (SCSIT DAVV), Indore and IIT Indore
Downloads 26
5.

Mutations in the Sphingolipid Pathway Gene SPTLC1 are a Cause of Amyotrophic Lateral Sclerosis

NEURON-D-19-00735
Number of pages: 85 Posted: 06 Jun 2019
Working Paper Series
National Institutes of Health - Neuromuscular Diseases Research Section, National Institutes of Health - Neuromuscular Diseases Research Section, Government of the United States of America - National Institutes of Health (NIH), University of London - Maurice Wohl Clinical Neuroscience Institute, National Institutes of Health - Neuromuscular Diseases Research Section, National Institutes of Health - Molecular Genetics Section, National Institutes of Health - Neuromuscular Diseases Research Section, United Kingdom Dementia Research Institute Centre, National Institutes of Health - Neurodegenerative Diseases Research Unit, National Institutes of Health - Computational Biology Core, National Institutes of Health - Computational Biology Core, National Institutes of Health, Government of the United States of America - National Institutes of Health (NIH), National Institutes of Health - Laboratory of Neurogenetics, Government of the United States of America - National Institutes of Health (NIH), Johns Hopkins University - School of Medicine, Johns Hopkins University - Department of Pathology, National Institutes of Health - Neurodegenerative Diseases Research Unit, National Institutes of Health - Neurodegenerative Diseases Research Unit, National Institutes of Health - Neurodegenerative Diseases Research Unit, Uniformed Services University of the Health Sciences, United Kingdom Dementia Research Institute Centre, University of London - Maurice Wohl Clinical Neuroscience Institute, University of London - Maurice Wohl Clinical Neuroscience Institute, University of London - Maurice Wohl Clinical Neuroscience Institute, University of London - Maurice Wohl Clinical Neuroscience Institute, University of Milan - Department of Neurology and Laboratory of Neuroscience, University of Massachusetts Worcester - Department of Neurology, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases, Macquarie University - Centre for MND Research, University of New South Wales (UNSW) - School of Medical Sciences (SoMS), University of New South Wales (UNSW) - School of Medical Sciences (SoMS), National Institutes of Health, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Southampton - Faculty of Medicine, Health and Life Sciences, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of London - Maurice Wohl Clinical Neuroscience Institute, University of Massachusetts Worcester - Department of Neurology, ASO OIRM-S.Anna, University of Turin - Department of Neurosciences, Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center, Hebrew University of Jerusalem, University of London - Maurice Wohl Clinical Neuroscience Institute, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Johns Hopkins University - Department of Pediatrics, University of London - Maurice Wohl Clinical Neuroscience Institute and University of Massachusetts Worcester - Department of Neurology
Downloads 25
6.

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Number of pages: 31 Posted: 14 Mar 2019
Working Paper Series
Cardiff University - Biomedicine division, Cardiff University - Biomedicine division, Cardiff University - Biomedicine division and Cardiff University - Biomedicine division
Downloads 22
7.

An Intramolecular Salt Bridge Linking TDP43's RNA Recognition Motifs Dictates RNA Binding and TDP43-Dependent Neurodegeneration

Number of pages: 70 Posted: 22 Aug 2018
Working Paper Series
University of Michigan at Ann Arbor - Cellular and Molecular Biology Graduate Program, University of Michigan at Ann Arbor - Department of Neurology, University of Michigan at Ann Arbor - Department of Pharmacology, University of Michigan at Ann Arbor - Department of Pharmacology and University of Michigan at Ann Arbor - Cellular and Molecular Biology Graduate Program
Downloads 15
8.

Spatio-Temporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

MOLECULAR-CELL-D-20-00180
Number of pages: 49 Posted: 19 Feb 2020
Working Paper Series
Weizmann Institute of Science - Department of Molecular Genetics, Weizmann Institute of Science - Department of Molecular Genetics, Harvard University - Division of Rheumatology, Immunology and Allergy, Tel Aviv University - Department of Human Molecular Genetics and Biochemistry, Weizmann Institute of Science - Department of Molecular Genetics, Weizmann Institute of Science - Department of Molecular Genetics, Weizmann Institute of Science - Department of Molecular Genetics, Weizmann Institute of Science - Department of Molecular Genetics, KU Leuven - Experimental Neurology, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Weizmann Institute of Science - Department of Molecular Genetics, Weizmann Institute of Science - Department of Molecular Genetics, KU Leuven - Experimental Neurology, Harvard University - Division of Rheumatology, Immunology and Allergy, Harvard University - Division of Rheumatology, Immunology and Allergy, Tel Aviv University - Department of Human Molecular Genetics and Biochemistry and Weizmann Institute of Science - Department of Molecular Genetics
Downloads 14
9.

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

Number of pages: 55 Posted: 08 Oct 2018
Working Paper Series
Istituto Italiano di Tecnologia - Center for Life Nano Science, University of Rome I - Department of Biology and Biotechnology Charles Darwin (BBCD), Istituto Italiano di Tecnologia - Center for Life Nano Science, University of Rome I - Department of Biology and Biotechnology Charles Darwin (BBCD), University of Rome I - Department of Biology and Biotechnology Charles Darwin (BBCD), University of Rome I - Department of Biology and Biotechnology Charles Darwin (BBCD), Istituto Italiano di Tecnologia - Center for Life Nano Science, Istituto Italiano di Tecnologia - Center for Life Nano Science, Utrecht University - Department of Translational Neuroscience, Helmholtz Association of German Research Centres - Berlin Institute for Medical Systems Biology, University of Amsterdam - Department of Neuropathology, University of Amsterdam, Academic Medical Center, Department of (Neuro)Pathology, Helmholtz Association of German Research Centres - Berlin Institute for Medical Systems Biology, Utrecht University - Department of Translational Neuroscience, University of Rome I - Department of Biology and Biotechnology Charles Darwin (BBCD) and Istituto Italiano di Tecnologia - Center for Life Nano Science
Downloads 13
10.

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Number of pages: 37 Posted: 03 Apr 2019
Working Paper Series
Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), affiliation not provided to SSRN, New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), Johns Hopkins University - Department of Neurology and Neurosurgery, New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), University of California, San Diego (UCSD) - Department of Neurosciences, The NYGC ALS Consortium and Cold Spring Harbor Laboratory
Downloads 13
11.

Stem Cell-Derived Cranial and Spinal Motor Neurons Reveal Proteostatic Differences between ALS Resistant and Sensitive Motor Neurons

Number of pages: 53 Posted: 10 Sep 2018
Working Paper Series
New York University (NYU) - Department of Biology, Boston Children’s Hospital - Department of Neurology, Columbia University - Department of Physiology and Cellular Biophysics, New York University (NYU) - Department of Biology, New York University (NYU) - Department of Biology, New York University (NYU) - Department of Biology, Boston Children’s Hospital - Department of Neurology, New York University (NYU) - Department of Biology, New York University (NYU) - Center for Genomics and Systems Biology, Columbia University - Department of Physiology and Cellular Biophysics, Boston Children’s Hospital - Department of Neurology and New York University (NYU) - Department of Biology
Downloads 12
12.

Cortico-Efferent Tract Involvement in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: A Two-Center Tract of Interest-Based DTI Analysis

Number of pages: 28 Posted: 01 Aug 2018
Working Paper Series
University of Ulm - Department of Neurology, Università Vita-Salute San Raffaele - Neuroimaging Research Unit, University of Ulm - Department of Neurology, University of Ulm - Department of Neurology, Università Vita-Salute San Raffaele - Neuroimaging Research Unit, Università Vita-Salute San Raffaele - Department of Neurology, University of Ulm - Department of Neurology, Università Vita-Salute San Raffaele - Neuroimaging Research Unit and University of Ulm - Department of Neurology
Downloads 11
13.

Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS

Number of pages: 40 Posted: 07 Jun 2018
Working Paper Series
Karolinska Institutet - Department of Clinical Neuroscience, Karolinska Institutet - Department of Clinical Neuroscience, Karolinska Institutet - Department of Clinical Neuroscience, Karolinska Institutet - Department of Clinical Neuroscience and Karolinska Institutet - Department of Clinical Neuroscience
Downloads 8
14.

Release of Motor Neuron Exosomes Containing TDP-43 and mTNF-α Near the Neuromuscular Junction Induces Skeletal Muscle Atrophy and Reduced Contractility in a 3D Human Model of ALS

NEURON-D-20-00389
Number of pages: 57 Posted: 21 Apr 2020
Working Paper Series
Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering, Dana-Farber Cancer Institute - Department of Medical Oncology, Dana-Farber Cancer Institute - Department of Medical Oncology, University of Calgary - Department of Medicine and Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering
Downloads 8
15.

Single-Cell RNA-Seq Analysis of Human iPSC-Derived Motor Neurons Resolves Early and Predictive ALS Signatures

CELL-STEM-CELL-D-20-00268
Number of pages: 79 Posted: 14 May 2020
Working Paper Series
Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Illumina, Inc., Illumina, Inc., Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, University of California, San Diego (UCSD) - Department of Neurosciences, University of California, San Diego (UCSD) - Department of Neurosciences, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Illumina, Inc., Illumina, Inc., University of California, San Diego (UCSD) - Department of Neurosciences, Illumina, Inc., Cedars Sinai Medical Center - Department of Neurology and Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute
Downloads 7
16.

The Calcium-Activated Chloride Channel TMEM16F Acts at C-Bouton to Modulate Motor Resistance and Contributes to ALS Pathogenesis

CELL-REPORTS-D-19-02801
Number of pages: 32 Posted: 23 Jul 2019
Working Paper Series
University of Montpellier - The Neuroscience Institute of Montpellier, University of Montpellier - The Neuroscience Institute of Montpellier, UNIMES - Université de Nîmes - Department of Biochemistry, University of Montpellier - The Neuroscience Institute of Montpellier, University of Montpellier - The Neuroscience Institute of Montpellier, University of Montpellier - The Neuroscience Institute of Montpellier, UNIMES - Université de Nîmes - Department of Biochemistry, University of Montpellier - The Neuroscience Institute of Montpellier and University of Montpellier - The Neuroscience Institute of Montpellier
Downloads 7
17.

Granulocyte-Colony Stimulating Factor: Encouraging Outcome in Sporadic ALS - Modelling and Bioinformatics Identify Substantial Filgrastim Responders

Number of pages: 48 Posted: 26 Jun 2020
Working Paper Series
affiliation not provided to SSRN, Department of Neurology, University Hospital Regensburg, Weil Institute of Neuroscience, Brain and Spinal Cord Injury Center, University of California, Lifedatascience Consulting, Department of Neurology, University Hospital Regensburg, Department of Neurology, University Hospital Regensburg, Department of Hematology -Internal Medicine III, University Hospital Regensburg, Department of Neurology, University Hospital Regensburg, Department of Neurology, University Hospital Regensburg, epartment of Neurology, University Hospital Regensburg, Department of Neurology, University Hospital Regensburg, Department of Psychiatry and Psychotherapy, University Hospital Regensburg, Department of Hematology -Internal Medicine III, University Hospital Regensburg,, Lifedatascience Consulting, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Department of Neurology, University Hospital Regensburg, Center of Neuroradiology, University Hospital Regensburg & District Medical Center Regensburg, BDS Koch, Department of Neurology, University Hospital Regensburg, University of California, San Francisco (UCSF) - Weill Institute for Neurosciences and University Hospital Regensburg - Department of Neurology
Downloads 6
18.

Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics

Number of pages: 27 Posted: 28 Mar 2019
Working Paper Series
Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Cell, Developmental, and Regenerative Biology, Mount Sinai Health System - Department of Neurology and Mount Sinai Health System - Department of Neurology
Downloads 5
19.

Human Amyotrophic Lateral Sclerosis Excitability Phenotype Screen: Target Discovery and Validation

CELL-STEM-CELL-D-20-00311
Number of pages: 30 Posted: 26 May 2020
Working Paper Series
Harvard University - F.M. Kirby Neurobiology Center, Harvard University - F.M. Kirby Neurobiology Center, Pfizer, Inc. - Medicine Design, Pfizer, Inc. - Medicine Design, Pfizer, Inc. - Rare Diseases Research, Pfizer, Inc. - Centers for Therapeutic Innovation (CTI), Pfizer, Inc. - Medicine Design, Pfizer Centers for Therapeutic Innovation (CTI), Pfizer, Inc. - Medicine Design, Pfizer Centers for Therapeutic Innovation (CTI), Pfizer Centers for Therapeutic Innovation (CTI), Harvard University - F.M. Kirby Neurobiology Center, Harvard University - Department of Stem Cell and Regenerative Biology, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - Department of Stem Cell and Regenerative Biology, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - F.M. Kirby Neurobiology Center, Harvard University - Department of Stem Cell and Regenerative Biology and Children's Hospital Boston - F.M. Kirby Neurobiology Center
Downloads 3
20.

A Brief Study on Motor Neuron Disease; and Its Treatment Includes Drug Delivery System; Future Aspects on Neurological Science

Number of pages: 5 Posted: 11 May 2020
Working Paper Series
Maharishi Markandeshwar University Mullana Ambala 133207
Downloads 2
21.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of ALS Patients

ISCIENCE-D-20-00475
Number of pages: 35 Posted: 10 Apr 2020
Working Paper Series
Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Houston Methodist Research Institute - Department of Neurology, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute, Cedars Sinai Medical Center - Board of Governors Regenerative Medicine Institute and Houston Methodist Research Institute - Department of Neurology
Downloads 2
22.

In Silico Design, Synthesis and Evaluation of Edaravone Co-Crystals with Improved Aqueous Solubility

Proceedings of International Conference on Drug Discovery (ICDD) 2020
Posted: 07 Feb 2020
Working Paper Series
Institute of Pharmacy & Technology, Institute of Pharmacy & Technology, Institute of Pharmacy & Technology, Institute of Pharmacy & Technology, affiliation not provided to SSRN, Institute of Pharmacy & Technology and Institute of Pharmacy & Technology
23.

Inhibition of Potential Target SOD1 Involved in Amyotrophic Lateral Sclerosis (ALS) by the Bioactive Compounds From Phyllanthus Acidus L.

Proceedings of International Conference on Drug Discovery (ICDD) 2020
Posted: 10 Feb 2020
Working Paper Series
Avinashilingam Institute for Home Science and Higher Education for Women, Alagappa University and Avinashilingam Institute for Home Science and Higher Education for Women