affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of the Basque Country - Biocruces Bizkaia Health Research Institute, affiliation not provided to SSRN, Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE, Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE, University of the Basque Country - Basque Center for Materials, Applications and Nanostructures (BCMaterials) and affiliation not provided to SSRN