affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of California, Los Angeles (UCLA) - David Geffen School of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Pennsylvania, University Hospital Zurich - Department of Radiation Oncology, Peter MacCallum Cancer Centre - Department of Radiation Oncology, University of Western Ontario - London Health Sciences Centre, affiliation not provided to SSRN and Leiden University - Leiden University Medical Center (LUMC)