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Structure-Guided Discovery of a Potent 2-Aryl-4-aminoquinazoline-Based Inhibitor Overcoming Osimertinib Resistance Driven by EGFR C797S Mutation in NSCLC

Number of pages: 29 Posted: 20 Feb 2026

Hao Chang, Cheng Zhang, Zhenyang Liang, Fang Liu, Yanhong Zhang, Jiaxin Tian, Zijie Xiao, Haohua Chi, Wenwen Du, Shu Li, Pengmei Li, Renzhong Qiao and Chao Li

Beijing University of Chemical Technology, Government of the People's Republic of China - China-Japan Friendship Hospital, Beijing University of Chemical Technology, Government of the People's Republic of China - China-Japan Friendship Hospital, Beijing University of Chemical Technology, Beijing University of Chemical Technology, Beijing University of Chemical Technology, Peking University, Government of the People's Republic of China - China-Japan Friendship Hospital, Government of the People's Republic of China - China-Japan Friendship Hospital, Government of the People's Republic of China - China-Japan Friendship Hospital, Beijing University of Chemical Technology and Beijing University of Chemical Technology

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Wenwen Du

Government of the People's Republic of China - China-Japan Friendship Hospital

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Scholarly Papers (1)

Structure-Guided Discovery of a Potent 2-Aryl-4-aminoquinazoline-Based Inhibitor Overcoming Osimertinib Resistance Driven by EGFR C797S Mutation in NSCLC

Abstract: