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Eleonora Giagnorio

Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’

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Stress-Response Dysregulation Underlies Selective Vulnerability of Motor Neurons in Bulbar-Onset Amyotrophic Lateral Sclerosis

Number of pages: 39 Posted: 05 Mar 2026
Stefania Marcuzzo, Eleonora Giagnorio, Marco Cattaneo, Claudia Malacarne, Giorgia Farinazzo, Maria Vizziello, Mehmeti Elkadia, Erika Salvi, Paolo Scalmani, Daniele Cartelli, Raffaella Lombardi, Samanta Mazzetti, Eleonora Dalla Bella, Nilo Riva, Antonella De Palma, Davide Perico, Pier Luigi Mauri, Ludo Van Den Bosch, Shahram Attarian, Emmanuelle Abgueguen, Pierre Miniou and Giuseppe Lauria Pinter
Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Research Council (CNR) - Institute for Biomedical Technologies (ITB), National Research Council (CNR) - Institute for Biomedical Technologies (ITB), National Research Council (CNR) - Institute for Biomedical Technologies (ITB), KU Leuven, Aix-Marseille University, InFlectis BioScience, InFlectis BioScience and Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’
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Bulbar‑onset ALS, stress‑vulnerable phenotype, stress-pathway modulation restores TDP‑43, proteostasis and excitability, EVs, miRNAs, phenotype-stratified ALS therapies