Southern Medical University, Southern Medical University, Southern Medical University - Clinical Research Centre, Southern Medical University, Sun Yat-sen University (SYSU) - Department of Cardiology, South China University of Technology - Clinical Research Centre, The Chinese University of Hong Kong (CUHK), The Chinese University of Hong Kong (CUHK), Southern Medical University, Southern Medical University, Southern Medical University - Clinical Research Centre, Sun Yat-sen University (SYSU) - Department of Medical Statistics and Epidemiology and Southern Medical University