affiliation not provided to SSRN, University of British Columbia (UBC) - Faculty of Pharmaceutical Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Indiana University Purdue University Indianapolis (IUPUI) - Indiana University School of Medicine, Indiana University Purdue University Indianapolis (IUPUI) - Indiana University School of Medicine, University of Iowa, University of Iowa, NASA Ames Research Center, Blue Marble Space Institute of Science, Carthage College, Carthage College, Carthage College, affiliation not provided to SSRN and affiliation not provided to SSRN