affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Pavia, affiliation not provided to SSRN, Nippon Medical School, affiliation not provided to SSRN, affiliation not provided to SSRN, Logan Hospital, University of Catania - Faculty of Medicine, University of Duisburg-Essen, The University of Sydney - Royal Prince Alfred Hospital, Harvard University - Division of Pulmonary and Critical Care Medicine, Stanford University, University of Cantabria, McGill University - Division of Rheumatology, Nippon Medical School - Department of Allergy and Rheumatology, Karolinska Institutet, Government of the Republic of Korea - National Institute of Health, University of Bath - Department of Life Sciences, Government of the Republic of Korea - National Institute of Health, University of Pittsburgh - School of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Autonomous University of Barcelona, University of Pennsylvania - Hospital of the University of Pennsylvania, affiliation not provided to SSRN, University of Catania - Faculty of Medicine, Hospital Universitario La Princesa, The University of Sydney, affiliation not provided to SSRN, University of Pavia and University of Pittsburgh - School of Medicine