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Taibao Wu

Sun Yat-sen University (SYSU)

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Oral Aminophylline Improves Assisted Reproductive Outcomes in Women of Advanced Age With Diminished Ovarian Reserve Through Phosphoinositide 3-kinase-dependent Mitochondrial Biogenesis

Number of pages: 31 Posted: 28 May 2026
Yingying Liu, Qiuli Wu, Yunlong Zhao, Jintao Peng, Dandan Wang, Huisi Mai, Jiana Huang, Jiayi Guo, Haitao Zeng, Xing Yang, Rui Huang, Taibao Wu, Chuanchuan Zhou, Meijia Zhang and Xiaoyan Liang
Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU) - Reproductive Medicine Center, Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU) - Reproductive Medicine Center, Sun Yat-sen University (SYSU) - Reproductive Medicine Center, Sun Yat-sen University (SYSU), Sun Yat-sen University (SYSU), South China University of Technology and Sun Yat-sen University (SYSU) - Reproductive Medicine Center
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Abstract:

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Aminophylline, Diminished ovarian reserve, Advanced age, Assisted reprodutive technology, PI3K-Akt signalling, Mitochondrial biogenesis, Cumulus granulosa cells