Sapienza University of Rome, affiliation not provided to SSRN, affiliation not provided to SSRN, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Fondazione Policlinico Universitario A. Gemelli IRCCS, affiliation not provided to SSRN, affiliation not provided to SSRN, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Sapienza University of Rome, Sapienza University of Rome, Johns Hopkins University, University of Kentucky, Sapienza University of Rome, Sapienza University of Rome, Sapienza University of Rome and Sapienza University of Rome