The University of Manchester - Manchester University NHS Foundation Trust, Golden Jubilee National Hospital, University of Bristol - Translational Health Sciences, Government of the United Kingdom - Sheffield Teaching Hospitals, Liverpool University Hospitals NHS Foundation Trust, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Infirmary of Edinburgh, University Hospitals Plymouth NHS Trust, Liverpool University Hospitals NHS Foundation Trust, University of Nottingham, The University of Manchester - Manchester University NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, Belfast Health and Social Care Trust, The University of Manchester - Manchester University NHS Foundation Trust and The University of Manchester - Manchester University NHS Foundation Trust