University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of São Paulo (USP) - Instituto de Ciências Biomédicas, University of Montreal - Faculté de Pharmacie, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, University of Toronto - Princess Margaret Cancer Centre, Vall d’Hebron Institute of Oncology (VHIO) - Preclinical Research Program, University of Montreal - Institut du Cancer de Montréal, Roche - Roche Innovation Center Zurich, University of São Paulo (USP) - Instituto de Ciências Biomédicas, Université de Rennes 1 - INSERM, University of Toronto - Princess Margaret Cancer Centre, Vall d’Hebron Institute of Oncology (VHIO) - Preclinical Research Program, University of Montreal - Faculté de Pharmacie and University of Toronto - Princess Margaret Cancer Centre