Zhejiang University - Center of Stem Cell and Regenerative Medicine, Zhejiang University - Center of Stem Cell and Regenerative Medicine, Sun Yat-sen University (SYSU) - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Michigan State University - Department of Biochemistry & Molecular Biology, Zhejiang University - Center of Stem Cell and Regenerative Medicine, Royal Institute of Technology (KTH) - Science for Life Laboratory (SciLife Lab), University of Edinburgh - Centre for Regenerative Medicine (Institute for Stem Cell Research), Harvard University - Department of Biostatistics and Computational Biology, Agency for Science, Technology and Research (A*STAR) - Stem Cell and Regenerative Biology, Harvard University - Department of Biostatistics and Computational Biology, Zhejiang University - Center of Stem Cell and Regenerative Medicine, University of Toronto - Developmental & Stem Cell Biology Program, The Jackson Laboratory - Jackson Laboratory for Genomic Medicine and Zhejiang University - Center of Stem Cell and Regenerative Medicine