University of Pittsburgh - Department of Pharmacology and Chemical Biology, University of Pittsburgh - Department of Pharmacology and Chemical Biology, University of Pittsburgh - Department of Pharmacology and Chemical Biology, Medical University of South Carolina - Department of Cell and Molecular Pharmacology, Imperial College London - Facility for Imaging by Light Microscopy, The Scripps Research Institute - Department of Chemistry, University of Pittsburgh - Department of Pharmacology and Chemical Biology, University of Pittsburgh - Department of Computational and Systems Biology, University of Pittsburgh - Department of Pharmacology and Chemical Biology, Medical University of South Carolina - Department of Cell and Molecular Pharmacology, University of Pittsburgh - School of Medicine, University of Pittsburgh - Department of Computational and Systems Biology, University of Pittsburgh - School of Medicine, Medical University of South Carolina - Department of Cell and Molecular Pharmacology, University of Galway - Centre for Chromosome Biology, Morehouse School of Medicine - Department of Pathology and Anatomy, The Scripps Research Institute - Department of Chemistry, University of Pittsburgh - Department of Pharmacology and Chemical Biology and University of Pittsburgh - Department of Pharmacology and Chemical Biology