University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill - Division of Chemical Biology and Medicinal Chemistry, Universidade Estadual de Campinas (UNICAMP) - Structural Genomics Consortium, University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill - Department of Cell Biology and Physiology, University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center, University of Cambridge - MRC Laboratory of Molecular Biology, University of Oxford - Target Discovery Institute, Universidade Estadual de Campinas (UNICAMP) - Structural Genomics Consortium, University of North Carolina (UNC) at Chapel Hill - Division of Chemical Biology and Medicinal Chemistry, Universidade Estadual de Campinas (UNICAMP) - Structural Genomics Consortium, University of Oxford - Target Discovery Institute, University of Oxford - Target Discovery Institute, Universidade Estadual de Campinas (UNICAMP) - Structural Genomics Consortium, University of North Carolina (UNC) at Chapel Hill - Division of Chemical Biology and Medicinal Chemistry, Goethe University Frankfurt - Structural Genomics Consortium, Universidade Estadual de Campinas (UNICAMP) - Structural Genomics Consortium, University of Oxford - Target Discovery Institute, University of North Carolina (UNC) at Chapel Hill - Division of Chemical Biology and Medicinal Chemistry, University of Oxford - Target Discovery Institute, University of North Carolina (UNC) at Chapel Hill - Division of Chemical Biology and Medicinal Chemistry, University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center and University of North Carolina (UNC) at Chapel Hill - Lineberger Comprehensive Cancer Center