Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Institute of Technology - School of Life Science and Technology, National Institutes for Quantum and Radiological Science and Technology - National Institute of Radiological Sciences, Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Medical University - Department of Nanoparticle Translational Research, Tokyo Medical University - Department of Nanoparticle Translational Research, National Institutes for Quantum and Radiological Science and Technology - National Institute of Radiological Sciences, National Center for Geriatrics and Gerontology, Tokyo Institute of Technology - School of Life Science and Technology, University of California, Los Angeles (UCLA) - Department of Microbiology, Immunology and Molecular Genetics and Tokyo Medical University - Department of Nanoparticle Translational Research