Columbia University - Department of Biochemistry and Molecular Biophysics, Columbia University - Department of Biochemistry and Molecular Biophysics, Columbia University - Department of Biochemistry and Molecular Biophysics, Columbia University - Department of Biochemistry and Molecular Biophysics, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, Yale University - Department of Molecular Biophysics and Biochemistry, Columbia University - Department of Biochemistry and Molecular Biophysics, Yale University - Department of Molecular Biophysics and Biochemistry, Columbia University - Mortimer B. Zuckerman Mind, Brain and Behavior Institute and Columbia University - Department of Biochemistry and Molecular Biophysics