Karolinska Institutet - Department of Physiology and Pharmacology, Karolinska Institutet - Department of Physiology and Pharmacology, Tianjin Medical University - Department of Neurosurgery, Chinese Academy of Sciences (CAS), Shanghai Institutes for Biological Sciences, Institute of Biochemistry and Cell Biology, State Key Laboratory of Cell Biology, Karolinska Institutet - Department of Medical Biochemistry and Biophysics, Children's Medical Research Institute (CMRI) - Embryology Unit, Chinese Academy of Sciences (CAS) - State Key Laboratory of Cell Biology and Karolinska Institutet - Department of Physiology and Pharmacology