Sapienza University of Rome, Sapienza University of Rome, Sapienza University of Rome, Sapienza University of Rome - School of Molecular Biology and Medicine, Istituto Superiore di Sanità, Sapienza University of Rome - IRCCS Ospedale Pediatrico Bambino Gesù, European Institute of Oncology (IEO) IRCCS, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST), Sapienza University of Rome, Università di Modena e Reggio Emilia, Sapienza University of Rome, IRCCS Ospedale Policlinico San Martino, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Catania, Veneto Institute of Oncology IOV - IRCCS, The AIRC Institute of Molecular Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Palermo, University of Insubria, University of Bologna, Centro di Riferimento Oncologico, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Sapienza University of Rome and Sapienza University of Rome