University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham - Nottingham Clinical Trials Unit, University of Sheffield - Health Economics and Decision Science Research Group (HEDS), University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University of Sheffield - Health Economics and Decision Science Research Group (HEDS) and University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology