University of Toronto - Donnelly Centre for Cellular and Biomolecular Research, Boston University - Department of Pharmacology and Experimental Therapeutics, University of Toronto - Donnelly Centre for Cellular and Biomolecular Research, University of Toronto - Donnelly Centre for Cellular and Biomolecular Research, Harvard University - Department of Surgery, Harvard University - Department of Surgery, Brigham and Women's Hospital - Center for Data Sciences, Cornell University - Department of Biological Statistics and Computational Biology, Cornell University - Department of Biological Statistics and Computational Biology, Cornell University - Department of Biological Statistics and Computational Biology, Boston University - Department of Pharmacology and Experimental Therapeutics, University of Toronto - Donnelly Centre for Cellular and Biomolecular Research, University of Regina - Department of Biochemistry, University of Regina - Department of Biochemistry, University of Toronto - Program in Molecular Medicine, University of Toronto - Donnelly Centre for Cellular and Biomolecular Research, Boston University - Department of Pharmacology and Experimental Therapeutics, Boston University - Department of Pharmacology and Experimental Therapeutics, Stanford University - Department of Genetics, Stanford University - Genetics Department, Boston University - Program in Bioinformatics, University of Milan - Department of Neurology and Laboratory of Neuroscience, Boston University - Department of Pharmacology and Experimental Therapeutics, University of Toronto - Program in Molecular Medicine, Harvard University - Department of Surgery, University of Regina - Department of Biochemistry, Cornell University - Department of Biological Statistics and Computational Biology, Boston University - Department of Pharmacology and Experimental Therapeutics, University of Toronto - Department of Molecular Genetics and University of Toronto - Donnelly Centre for Cellular and Biomolecular Research