University of Kansas, University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas, University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas, University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, University of California, Santa Cruz, Jack Baskin School of Engineering, Department of Biomedical Engineering, University of California, Santa Cruz, Jack Baskin School of Engineering, Department of Biomedical Engineering and University of Kansas, University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics