RWTH Aachen University - Helmholtz Institute for Biomedical Engineering, University of Cologne - Center for Molecular Medicine Cologne (CMMC), Hannover Medical School - Institute of Experimental Hematology, University of Nottingham - School of Biosciences, University of Cologne - Center for Molecular Medicine Cologne (CMMC), RWTH Aachen University - Helmholtz Institute for Biomedical Engineering, RWTH Aachen University - Helmholtz Institute for Biomedical Engineering, RWTH Aachen University - Institute of Human Genetics, RWTH Aachen University - Department for Orthopedics, Heidelberg University Medical Center - Internal Medicine, Hannover Medical School - Institute of Experimental Hematology, Hannover Medical School - Institute of Experimental Hematology, University of Göttingen - Translational Epigenetics Group and RWTH Aachen University - Helmholtz Institute for Biomedical Engineering