The University of Hong Kong, National Cancer Center, Korea, University of California, Los Angeles (UCLA) - David Geffen School of Medicine, National Taiwan University - Department of Internal Medicine, Anger University Hospital - HepatoGastroenterology Department, Centre Eugène Marquis - Medical Oncology, Kindai University - Department of Gastroenterology and Hepatology, Memorial Sloan Kettering Cancer Center - Department of Medicine, Croix Rousse Hospital - Hepatology Unit, Sorbonne University - ssistance Publique Hôpitaux de Paris, M. Sklodowska-Curie Memorial National Cancer Research Institute, University Hospital Ulm - Helios Klinikum Emil von Behring GmbH, National Cancer Centre Singapore - Division of Medical Oncology, University of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center, Medical University of Vienna - Department of Internal Medicine III, Hôpital Avicenne (APHP) - Centre Hospitalier Universitaire de Montpellier,, Medical University of Gdańsk - Department of Clinical Oncology and Radiotherapy, Kyorin University - Department of Medical Oncology, Memorial Sloan Kettering Cancer Center - Department of Medicine, University of Southern California - Norris Comprehensive Cancer Center, University of Navarra - Department of Cardiology and Cardiovascular Surgery, Bristol Myers Squibb, Bristol Myers Squibb, Bristol Myers Squibb, Bristol Myers Squibb, Bristol Myers Squibb and Carlos III National Institute of Health - Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd)

National Taiwan University - College of Medicine, Fu-Jen Catholic University, National Taiwan University - Department of Oncology, National Health Research Institutes - Division of Environmental Health and Occupational Medicine, National Taiwan University - Graduate Institute of Epidemiology and Preventive Medicine, Academia Sinica - Genomics Research Center, Mackay Medical College - Department of Medicine, Fu-Jen Catholic University, Academia Sinica - Genomics Research Center, Academia Sinica - Genomics Research Center, National Health Research Institutes - Institute of Population Health Sciences, National Taiwan University - Department of Oncology, National Taiwan University - Department of Internal Medicine, National Health Research Institutes - Division of Environmental Health and Occupational Medicine, National Health Research Institutes - Institute of Population Health Sciences and Academia Sinica - Genomics Research Center

National Health Research Institutes - National Institute of Cancer Research, National Health Research Institutes - National Institute of Cancer Research, National Health Research Institutes - National Institute of Cancer Research, National Taiwan University - Department of Internal Medicine, National Taiwan University - National Taiwan University Hospital (NTUH), National Taiwan University - Department of Pathology, Mackay Memorial Hospital, National Taiwan University - Department of Internal Medicine, Kaohsiung Medical University - Department of Internal Medicine, National Taiwan University - Department of Internal Medicine, National Health Research Institutes - National Institute of Cancer Research, National Taiwan University - Department of Internal Medicine, Taichung Veterans General Hospital, Taichung Veterans General Hospital, Mackay Memorial Hospital, Kaohsiung Veterans General Hospital, Kaohsiung Veterans General Hospital, Changhua Christian Hospital - Department of Internal Medicine, Chi-Mei Medical Center, Chi-Mei Medical Center, National Taiwan University - Department of Internal Medicine, National Taiwan University - Department of Pathology, China Medical University - School of Medicine, Kaohsiung Medical University - Department of Internal Medicine, China Medical University - College of Medicine, National Health Research Institutes - National Institute of Cancer Research, China Medical University, National Taiwan University - Division of Radiation Oncology, National Taiwan University - Department of Internal Medicine and Independent

Kindai University - Department of Gastroenterology and Hepatology, University of California, Los Angeles (UCLA) - David Geffen School of Medicine, Nanjing Bayi Hospital, Yonsei University - Severance Hospital, Toranomon Hospital - Department of Hepatology, National Taiwan University - Department of Internal Medicine, University of Bologna, Kindai University - Faculty of Medicine, Hiroshima University - Hiroshima University Hospital, Hannover Medical School - Department of Gastroenterology, Hepatology and Endocrinology, Hospital Marqués de Valdecilla, Comprehensive Cancer Center Eugène Marquis, Fudan University - Shanghai Cancer Center (FUSCC), Azienda Ospedaliera G. Rummo, National Cancer Center, Korea, Clatterbridge Cancer Centre, Eisai, Inc. - Eisai, Inc. - United States, Eisai, Inc., Eisai, Inc. - Eisai, Inc. - United States and University of Miami - Miller School of Medicine