Lund University - Skåne University Hospital, University of Exeter - Institute of Biomedical and Clinical Science, University of Exeter - Institute of Biomedical and Clinical Science, University of Exeter - Institute of Biomedical and Clinical Science, Lund University - Skåne University Hospital, University of Gothenburg - Sahlgrenska University Hospital, Royal Devon and Exeter NHS Foundation Trust, Department of Molecular Genetics, Lund University - Skåne University Hospital, Lund University - Skåne University Hospital, Lund University - Skåne University Hospital, Lund University - Skåne University Hospital, Linkoping University, Karolinska Institutet, University of Helsinki, Linkoping University, Karolinska Institutet - Department of Clinical Science, Intervention and Technology and University of Exeter - Institute of Biomedical and Clinical Science