Niccolo Tesí

VU University Amsterdam

De Boelelaan 1105

Amsterdam, ND North Holland 1081 HV

Netherlands

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A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy-Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity

Number of pages: 37 Posted: 01 Feb 2019
Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R. Van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J. Keogh, Kaj Blennow, Ingmar Skoog, Manuel A. Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adela Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesí, Christopher Morris, Begoña Indakoetxea, Lyduine E. Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W. Ironside, Bart. N.M. van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L. Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, DESGESCO Dementia Genetics Spanish Consortium, Alzheimer Disease European DNA Biobank, IFGC International FTD-Genomics Consortium, IPDGC The International Parkinson Disease Genomics Consortium, RiMod-FTD Rsk and Modifying factors in Fronto-Temporal Dementia, Netherlands Brain Bank (NBB), Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Jay A. van Gerpen, Marcel J. T. Reinders, Ryan J. Uitti, Lluis Tarraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K. Zettl, Natasja M. van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K. Wszolek, Owen A. Ross, Dennis W. Dickson, Neill R. Graff-Radford, David Knopman, Rosa Rademakers, Afina W. Lemstra, Yolande A. L. Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F. Chinnery, Bernhard Hemmer, Martijn A. Huisman, Juan Troncoso, Fermin Moreno, Ellen A. Nohr, Thorkild I. A. Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, Giovanni Coppola, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W. Scholz, Alfredo Ramirez, Agustin Ruiz, Eline Slagboom, Wiesje M. van der Flier and Henne Holstege
VU University Amsterdam, Mayo Clinic - Florida, VU University Amsterdam - Department of Neurology, Mayo Clinic - Florida, University of Cologne - Division of Neurogenetics and Molecular Psychiatry, Leiden University - Leiden University Medical Center (LUMC), Universitat Internacional de Catalunya, Utrecht University - Department of Neurology, VU University Amsterdam - Amsterdam Public Health Research Institute, University of California, Los Angeles (UCLA), University of Gothenburg, Max Planck Institute of Psychiatry, Hospital Universitario Mutua de Terrassa, German Center for Neurodegenerative Diseases (DZNE), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Gothenburg - Institute of Neuroscience and Physiology, University of Southern Denmark, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), VU University Amsterdam, University of Southern Denmark, Universitat Internacional de Catalunya, Bonn University, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Newcastle, University of Gothenburg - Institute of Neuroscience and Physiology, University of Gothenburg, German Competence Network Multiple Sclerosis (KKNMS), Johns Hopkins University - School of Medicine, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), affiliation not provided to SSRN, Carlos III Institute of Health, University of Leipzig - Institute for Social Medicine, Occupational Health and Public Health, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Cambridge, University of Southern Denmark, Universitat Internacional de Catalunya, German Competence Network Multiple Sclerosis (KKNMS), Mayo Clinic - Florida, VU University Amsterdam - Department of Neurology, VU University Amsterdam, VU University Amsterdam, University of Newcastle, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), VU University Medical Center, University of Hamburg - University Medical Center Hamburg-Eppendorf, Utrecht University - University Medical Center (Utrecht), University of Edinburgh, VU University Medical Center, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), German Competence Network Multiple Sclerosis (KKNMS), Mayo Clinic - Florida, Hospital Universitario Mutua de Terrassa, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Independent, Independent, Independent, Independent, Independent, Independent, Mayo Clinic, Mayo Clinic, Mayo Clinic - Florida, Mayo Clinic - Florida, Delft University of Technology, Mayo Clinic - Florida, Universitat Internacional de Catalunya, University of Bonn - Department of Neurodegenerative Disease and Gerontopsychiatry, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Cologne - University Hospital of Cologne, University of Cologne - University Hospital of Cologne, Universitat Internacional de Catalunya, German Competence Network Multiple Sclerosis (KKNMS), University of Amsterdam - Amsterdam Public Health Research Institute, Leiden University - Section of Molecular Epidemiology, Mayo Clinic - Florida, Government of the United States of America - National Institutes of Health (NIH), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Johns Hopkins University - School of Medicine, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic - Florida, Mayo Clinic, Mayo Clinic - Florida - Department of Neuroscience, VU University Amsterdam, VU University Amsterdam, VU University Amsterdam - Department of Neurology, University of Tuebingen, University of Hamburg - University Medical Center Hamburg-Eppendorf, Technische Universität München (TUM), VU University Amsterdam - Amsterdam Public Health Research Institute, Johns Hopkins University - Department of Pathology, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Southern Denmark - Institute of Clinical Research, University of Copenhagen - Section of Metabolic Genetics, German Center for Neurodegenerative Diseases (DZNE), Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), VU University Medical Center, University of California, Los Angeles (UCLA) - Department of Neurology, Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), University of Southern Denmark, VU University Amsterdam, National Institutes of Health - Neurodegenerative Diseases Research Unit, University of Cologne - Division of Neurogenetics and Molecular Psychiatry, Universitat Internacional de Catalunya, Leiden University - Leiden University Medical Center (LUMC), University of Bonn - Institute of Innate Immunity and VU University Amsterdam - Alzheimer Center Amsterdam
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Citation 23

Abstract:

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Alzheimer's Disease, frontotemporal dementia, dementia with Lewy-bodies, progressive suprauclear palsy, Parkinson's Disease, amyotrophic lateral sclerosis, multiple sclerosis, neurodegenerative disease, longevity, PLCG2, Phospholipase C Gamma 2