Department of Health Sciences (DISSAL), Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Department of Health Sciences, University of Genova, Department of Health Sciences, University of Genova, Centro Sclerosi Multipla ASST Spedali Civili di Brescia, Department of Neurology, Multiple Sclerosis Center, IRCCS Ospedale San Raffaele, Department of Neurology and Multiple Sclerosis Center, ASST “Papa Giovanni XXIII, Multiple Sclerosis Center, Ospedale Guglielmo da Saliceto, Regional Referral Multiple Sclerosis Centre, Dept. of Neurology, University Hospital San Luigi, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Research Department, Italian Multiple Sclerosis Foundation, University of Campania “Luigi Vanvitelli” - First Division of Neurology, Institute of Experimental Neurology, IRCCS Ospedale San Raffaele, Research Department, Italian Multiple Sclerosis Foundation, Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, University of Rome I - Department of Neuroscience, Mental Health and Sensory Organs and affiliation not provided to SSRN

Heinrich Heine University Dusseldorf - Department of Neurology, University of Basel - University Hospital Basel, University of California, San Francisco (UCSF) - Weill Institute for Neurosciences, Department of Health Sciences (DISSAL), Medical University of Lodz, University College London - Institute of Neurology, University College London - Institute of Neurology, University College London - Institute of Neurology, Servier International Research Institute (IRIS), GeNeuro SA, GeNeuro SA, Servier International Research Institute (IRIS), GeNeuro SA, GeNeuro SA and VU University Amsterdam - Neuroscience Campus Amsterdam