Tongji University - Clinical Translational Research Center, University of Massachusetts Worcester, Medical School, Program in Molecular Medicine, University of Queensland - School of Chemistry & Molecular Biosciences, University of Queensland - School of Agriculture and Food Sciences, University of Queensland - School of Agriculture and Food Sciences, University of Massachusetts Worcester, Medical School, Program in Molecular Medicine, University of Massachusetts Worcester - Program in Molecular Medicine, University of Massachusetts Worcester - Program in Bioinformatics and Integrative Biology (BIB) and University of Massachusetts Worcester - Program in Molecular Medicine