Johns Hopkins University - Department of Oncology, Johns Hopkins University, Johns Hopkins University - Department of Applied Mathematics and Statistics, Brock University, Johns Hopkins University - Department of Surgery, Johns Hopkins University - Department of Surgery, Johns Hopkins University - Department of Oncology, British Columbia Cancer Agency, Johns Hopkins University - Department of Applied Mathematics and Statistics, Johns Hopkins University - Russell H. Morgan Department of Radiology and Radiological Science, National Cancer Institute (Canada), Vancouver General Hospital, University of Toronto - Princess Margaret Cancer Centre, Université Laval - University Institute of Cardiology and Respirology of Quebec, Université Laval - University Institute of Cardiology and Respirology of Quebec, Henderson Hospital, Henderson Hospital, The Ottawa Health Research Institute (OHRI), Dalhousie University, University of Calgary, Memorial University, University of Toronto - Princess Margaret Cancer Centre and British Columbia Cancer Agency