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Nathalie Rufer

University of Lausanne - Department of Oncology

Rue du Bugnon 46

Lausanne, +41 21 314 11 11 1011

Switzerland

  • University of Lausanne - Department of Oncology

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Chronic TCR-MHC (Self)-Interactions Limit the Functional Potential of TCR Affinity-Increased CD8 T Lymphocytes

Number of pages: 64 Posted: 11 Jun 2019
Minh Ngoc Duong, Efe Erdes, Michael Hebeisen and Nathalie Rufer
University of Lausanne - Department of Oncology, University of Lausanne - Department of Oncology, University of Lausanne - Department of Oncology and University of Lausanne - Department of Oncology
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Abstract:

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human, immunotherapy, preclinical testing, CD8 T cells, NY-ESO-1 tumor antigen, TCR engineered, TCR affinity optimization, TCR-A2 (self)-interactions, TCR/CD3 complex, T cell signaling, T cell functionality