University of Ferrara - Department of Medical Sciences, Karolinska Institutet - Aging Research Centre, University of Milano-Bicocca - School of Medicine and Surgery, University of Brescia - Department of Information Engineering, University of Milano-Bicocca - Centre of Biostatistics for Clinical Epidemiology, University of Brescia - Department of Clinical and Experimental Sciences, University of Besançon - University Hospital Besançon, University of Brescia - Department of Clinical and Experimental Sciences and Milano-Bicocca University - School of Medicine and Surgery