University of Lisbon - Institute of Molecular Medicine, University of Lisbon - Institute of Molecular Medicine, University of Pennsylvania - Department of Systems Pharmacology and Translational Therapeutics, University of Lisbon - Instituto de Medicina Molecular (iMM), German Cancer Research Center (DKFZ), University of Lisbon - Instituto de Medicina Molecular (iMM), University of Lisbon - Instituto de Medicina Molecular (iMM), University of Pennsylvania - Department of Systems Pharmacology and Translational Therapeutics, University of Lisbon - Instituto de Medicina Molecular (iMM), German Cancer Research Center (DKFZ), German Cancer Research Center (DKFZ), Centro Hospitalar Universitário Lisboa Norte (CHLN), University of La Rioja, University of Lisbon - Instituto de Medicina Molecular (iMM), University of Lisbon - Instituto de Medicina Molecular (iMM), University of Lisbon - Instituto de Medicina Molecular (iMM), University of Pennsylvania - Department of Systems Pharmacology and Translational Therapeutics and University of Lisbon - Instituto de Medicina Molecular (iMM)