Sun Yat-sen University (SYSU) - Scientific Research Center, The University of Hong Kong - School of Public Health, University of Bristol - Medical Research Council Integrative Epidemiology Unit, The Chinese University of Hong Kong (CUHK) - School of Public Health and Primary Care, The Chinese University of Hong Kong (CUHK) - School of Public Health and Primary Care, Sun Yat-sen University (SYSU) - Seventh Affiliated Hospital, Sun Yat-sen University (SYSU) - Department of Gastrointestinal Surgery, Sun Yat-sen University (SYSU) - Digestive Medical Center, The Chinese University of Hong Kong (CUHK) - School of Public Health and Primary Care, Sun Yat-sen University (SYSU) - Scientific Research Center and University of Southampton - Primary Care and Population Science